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Alterations of default mode functional connectivity in individuals with end-stage renal disease and mild cognitive

Haitao Lu1, Zhengzhang Gu1, Wei Xing2

  • 1Department of Radiology, The Third Affiliated Hospital of Soochow University, Changzhou, China.

BMC Nephrology
|July 7, 2019
PubMed
Abstract

Insights

End-stage renal disease (ESRD) patients with mild cognitive impairment (MCI) show reduced default-mode network (DMN) functional connectivity. This DMN alteration is linked to lower hemoglobin and cognitive test scores, suggesting a neuropathological basis.

Area of Science:

  • Neuroscience
  • Nephrology
  • Cognitive Science

Background:

  • Mild cognitive impairment (MCI) is prevalent in end-stage renal disease (ESRD) patients, impacting prognosis.
  • The underlying neuropathological mechanisms linking ESRD and MCI remain unclear.
  • This study investigates default-mode network (DMN) functional connectivity (FC) in ESRD patients with MCI.

Purpose of the Study:

  • To examine alterations in DMN functional connectivity (FC) in individuals with ESRD and MCI.
  • To correlate these FC changes with neuropsychological and clinical variables.

Main Methods:

  • Resting-state functional MRI and neuropsychological tests were administered to 24 ESRD patients with MCI and 25 controls.
  • Independent component analysis (ICA) characterized the DMN.
  • Voxel-wise t-tests compared FC between groups, with correlations to clinical data.

Main Results:

  • ESRD patients with MCI exhibited significantly decreased DMN functional connectivity in the posterior cingulate cortex (PCC)/precuneus (Pcu) and medial prefrontal cortex (MPFC).
  • Reduced FC in MPFC and PCC/Pcu correlated positively with hemoglobin levels.
  • MPFC FC reduction also positively correlated with Montreal Cognitive Assessment (MoCA) scores.

Conclusions:

  • Decreased DMN functional connectivity is associated with neuropathological mechanisms in ESRD patients with MCI.
  • These findings highlight potential neuroimaging biomarkers for cognitive impairment in ESRD.
Keywords:
End stage renal diseaseMild cognitive impairmentResting state fMRI

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