Related Experiment Video

Updated: Jan 20, 2026

Detection of Aggregation-Prone Behavior in Mutant P53 V157F Breast Cancer Cells Using Multipoint Thioflavin T Fluorescence
12:09

Detection of Aggregation-Prone Behavior in Mutant P53 V157F Breast Cancer Cells Using Multipoint Thioflavin T Fluorescence

Published on: December 30, 2025

24

Targeting mutant p53 in cancer: the latest insights

Silvia Di Agostino1, Giulia Fontemaggi2, Sabrina Strano2

  • 1Oncogenomic and Epigenetic Unit, Department of Research, Diagnosis and Innovative Technologies, IRCCS Regina Elena National Cancer Institute, 00144, Rome, Italy. silvia.diagostino@ifo.gov.it.

Journal of Experimental & Clinical Cancer Research : CR
|July 7, 2019
PubMed

Insights

Latest discoveries in mutant p53 (mutp53) proteins reveal their role in human cancer pathogenesis. Understanding mutp53 gain-of-function (GOF) is key to developing novel cancer therapies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Mutant p53 (mutp53) proteins are implicated in the development of most human cancers.
  • These mutant proteins can lose their normal tumor-suppressive functions.
  • Mutp53 may also gain new oncogenic functions, promoting cancer progression.
Keywords:
Cancer-associated fibroblastsExosomesLi-FraumeniMutant p53 reactivationSmall moleculesmiRNAp53

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