Grape seed extract supplement increases bone callus formation and mechanical strength: an animal study
Murat Gurger1, Erhan Yilmaz2, Seval Yilmaz3
1Department of Orthopaedics and Traumatology, Faculty of Medicine, Firat University, 23119, Elazig, Turkey. muratgurger@hotmail.com.
Journal of Orthopaedic Surgery and Research
|July 7, 2019
Summary
Grape seed proanthocyanidin extract (GSPE) enhances bone fracture healing and improves bone strength. This antioxidant shows promise for accelerating recovery and strengthening bones post-fracture.
Area of Science:
- Biomedical Science
- Orthopedics
- Pharmacology
Background:
- Grape seed proanthocyanidin extract (GSPE) is a known antioxidant with established bone health benefits.
- Limited research exists on GSPE's specific impact on fracture healing and bone biomechanics.
Purpose of the Study:
- To investigate the effects of GSPE on the process of bone fracture healing.
- To evaluate the impact of GSPE on the biomechanical properties of healing bone.
Main Methods:
- Sixty-four male rats underwent femur osteotomy and fixation.
- GSPE was administered orally (100 mg/kg/day) to experimental groups.
- Histopathological, radiological, and biomechanical analyses were performed at 10, 20, and 30 days post-surgery.
Main Results:
- GSPE supplementation significantly improved bone healing, evidenced by enhanced histopathological findings in callus tissues.
- Radiological assessments showed statistically significant improvements in recovery scores and callus volume with GSPE.
- Biomechanical testing revealed that GSPE increased bone strength in both fracture and control groups.
Conclusions:
- GSPE, a potent antioxidant, positively influences bone fracture healing.
- GSPE supplementation enhances the mechanical strength of healing bone, suggesting therapeutic potential.
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