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Asthma-I: Introduction

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...

Asthma-II: Pathophysiology and Classification

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:

Asthma: Pathogenesis and Management

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.

Asthma-III: Symptoms and Complications

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma

Asthma-IV: Diagnostic and Management

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:

Asthma-IV: Nursing Management

Asthma-IV: Nursing Management

The nursing management of asthma is a comprehensive approach that relies heavily on the expertise and dedication of healthcare professionals. It involves thorough assessment, accurate diagnosis, strategic planning, effective implementation, and diligent evaluation. By meticulously following this step-by-step process, healthcare professionals play a crucial role in providing the best possible care and treatment for patients with asthma, enhancing their overall health and well-being.
First, in...

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Updated: Jan 22, 2026

Acupuncture in a Rat Model of Asthma

Acupuncture in a Rat Model of Asthma

Published on: August 25, 2020

Leveraging -omics for asthma endotyping.

Scott R Tyler¹, Supinda Bunyavanich²

¹Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY.

The Journal of Allergy and Clinical Immunology

|July 7, 2019

Summary

This summary is machine-generated.

Asthma subtypes, or endotypes, are identified using various methods, including advanced

Keywords:

-ome -omic Asthma cluster endotype epigenome integrate metabolome microbiome multi-ome phenotype proteome transcriptome

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Area of Science:

Pulmonology and Respiratory Medicine
Genomics and Bioinformatics
Systems Biology

Background:

Asthma is a complex respiratory condition characterized by significant heterogeneity in symptoms, triggers, and disease progression.
This variability necessitates precise subtyping (endotyping) to understand underlying pathophysiological mechanisms and personalize treatment strategies.
Current endotyping approaches utilize clinical data, laboratory parameters, and emerging -omics technologies.

Purpose of the Study:

To review the application of diverse -omics approaches for asthma endotyping.
To highlight how -omics data can refine existing asthma endotypes and propose novel classifications.
To discuss the integration of multi-omics data with clinical and laboratory findings for precise asthma endotyping.

Main Methods:

Comprehensive review of -omics technologies applied to asthma research, including transcriptomics, epigenomics, microbiomics, metabolomics, and proteomics.
Analysis of how these -omics data contribute to understanding asthma heterogeneity and endotype development.
Exploration of strategies for integrating multi-omics datasets with traditional clinical and laboratory parameters.

Main Results:

-Omics approaches have validated existing asthma endotyping paradigms and introduced new conceptual frameworks.
Single -omics applications are common, but integrated multi-omics approaches for asthma endotyping remain less explored.
Evidence supports the utility of -omics data in revealing distinct molecular mechanisms underlying asthma subtypes.

Conclusions:

Multi-omics integration holds significant promise for developing highly precise asthma endotypes.
Combining multi-omics data with clinical and laboratory features is crucial for advancing personalized asthma management.
Future research should focus on robust multi-omics integration strategies to achieve precise endotyping and targeted therapies.