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Complete response with neoadjuvant avelumab in Merkel cell carcinoma - A case report
Nadine Abdallah1, Misako Nagasaka2, Tahmida Chowdhury3
1Department of Internal Medicine, Wayne State University, Detroit, MI, USA.
Abstract:
Merkel cell carcinoma (MCC) is a rare but aggressive neuroendocrine skin malignancy. We report here a case of localized MCC achieving pathologic complete response upon treatment with avelumab in the neoadjuvant setting. Preclinical and clinical studies have revealed a close relationship between MCC and the immune system, thus supporting a role for PD-1/PD-L1 inhibitors in MCC. This neoadjuvant use of PD-1/PD-L1 inhibitors can avoid potentially disfiguring surgery in MCC. As the incidence of MCC is rising, clinical trials are needed to evaluate the efficacy and safety of immunotherapy in resectable disease.
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