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Updated: Jan 22, 2026

Antigenic Liposomes for Generation of Disease-specific Antibodies

Antigenic Liposomes for Generation of Disease-specific Antibodies

Published on: October 25, 2018

Alternative tumour-specific antigens.

Christof C Smith^1,2, Sara R Selitsky^2,3, Shengjie Chai^1,2,4

¹Department of Microbiology and Immunology, UNC School of Medicine, Marsico Hall, Chapel Hill, NC, USA.

Nature Reviews. Cancer

|July 7, 2019

Summary

This summary is machine-generated.

Alternative tumour-specific antigens (TSAs) from non-SNV sources offer new therapeutic targets. These antigens, unlike patient-specific neoantigens, can be shared across tumors, enabling universal cancer therapies.

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Published on: August 11, 2014

Area of Science:

Oncology
Immunology
Genomics

Background:

Tumour-specific antigens (TSAs) are crucial for developing targeted antitumour therapies.
Non-synonymous single-nucleotide variant (SNV) neoantigens are the most studied class of TSAs.
Expanding the repertoire of therapeutic targets necessitates exploring alternative TSA sources.

Purpose of the Study:

To review alternative tumour antigens derived from non-SNV genomic alterations.
To discuss the biology, detection tools, and clinical relevance of these alternative TSAs.
To highlight challenges and solutions for the clinical translation of alternative TSA-based therapies.

Main Methods:

Literature review and synthesis of current research on alternative TSAs.
Analysis of biological mechanisms underlying alternative TSA generation.
Evaluation of computational tools for identifying alternative TSAs.
Review of preclinical and clinical studies involving alternative TSAs.

Main Results:

Alternative TSAs arise from various non-SNV sources, including frameshifts, splice variants, and gene fusions.
Some alternative TSAs are shared across multiple tumors, offering potential for universal therapies.
Computational tools and preclinical/clinical studies are emerging for alternative TSA evaluation.

Conclusions:

Alternative TSAs represent a promising avenue for expanding cancer immunotherapy targets.
The shared nature of some alternative TSAs could lead to 'off-the-shelf' therapeutic strategies.
Overcoming current challenges is key to realizing the clinical potential of alternative TSAs.