Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

934
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
934
Drugs for Treatment of Ulcerative Colitis in IBD01:29

Drugs for Treatment of Ulcerative Colitis in IBD

476
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
476
Peptic Ulcer Disease II: Pathophysiology01:28

Peptic Ulcer Disease II: Pathophysiology

2.0K
Peptic Ulcer Disease (PUD) is characterized by the development of ulcers in the stomach or duodenal mucosa. Its pathophysiology is complex, involving a balance between damaging and protective elements.
Damaging agents such as Helicobacter pylori, gastric acid, pepsin, and nonsteroidal anti-inflammatory drugs (NSAIDs) can weaken the mucosal defense, allowing hydrogen ions to infiltrate back and harm epithelial cells.
2.0K
Peptic Ulcer Disease I: Introduction01:30

Peptic Ulcer Disease I: Introduction

760
Peptic Ulcer Disease (PUD) is characterized by mucosal excavation in the esophagus, stomach, pylorus, or duodenum. It can manifest as acute or chronic based on the extent and duration of mucosal involvement.
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
760
Peptic Ulcer Disease IV: Management01:26

Peptic Ulcer Disease IV: Management

449
Medical treatment strategies for peptic ulcers encompass various methods. The primary goal of treatment is to diminish gastric acidity and strengthen mucosal defense mechanisms.
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
449
Pathophysiology of Peptic Ulcer Disease: Injurious Factors01:22

Pathophysiology of Peptic Ulcer Disease: Injurious Factors

1.1K
Peptic ulcers are sores on the stomach's inner lining and the upper small intestine, which are the result of disruptions in the mucosal layer that houses parietal cells which produce gastric acid, and chief cells which secrete pepsinogen.
In the antrum region, G cells secrete the gastrin hormone that binds to gastrin-cholecystokinin-B (CCK2) receptors on parietal and enterochromaffin-like (ECL) cells in the fundic glands. Simultaneously, the vagus nerve releases acetylcholine, which binds...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The JAK1/3 inhibitor tofacitinib suppresses T cell homing and activation in chronic intestinal inflammation.

Journal of Crohn's & colitis·2020
Same author

Role of the IL-2 inducible tyrosine kinase ITK and its inhibitors in disease pathogenesis.

Journal of molecular medicine (Berlin, Germany)·2020
Same author

Functional Molecular Network Analysis Enables Prediction of Response to Vedolizumab Therapy in Anti-TNF Refractory IBD Patients.

Crohn's & colitis 360·2020
Same author

Topical application of Chlorin e6-PVP (Ce6-PVP) for improved endoscopic detection of neoplastic lesions in a murine colitis-associated cancer model.

Scientific reports·2020
Same author

Vascular occlusion by neutrophil extracellular traps in COVID-19.

EBioMedicine·2020
Same author

Patients with immune-mediated inflammatory diseases receiving cytokine inhibitors have low prevalence of SARS-CoV-2 seroconversion.

Nature communications·2020
Same journal

The interaction between inflammation and estrogen in adenomyosis : from molecular mechanisms to therapeutic strategies.

Seminars in immunopathology·2026
Same journal

The complex of gut microbial metabolites and sex hormones in Alzheimer's disease.

Seminars in immunopathology·2026
Same journal

Endometrial pathophysiology and pregnancy: from mechanism to intervention.

Seminars in immunopathology·2026
Same journal

Advances in understanding the dual roles of testicular immune responses: From immune privilege to inflammation.

Seminars in immunopathology·2026
Same journal

Climate change-associated heat extremes and immune dysregulation: emerging links with autoimmunity, allergy, and infectious diseases.

Seminars in immunopathology·2026
Same journal

The cancer-microbiome axis: Mechanisms and emerging therapeutic strategies.

Seminars in immunopathology·2026
See all related articles

Related Experiment Video

Updated: Jan 22, 2026

Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis
06:19

Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis

Published on: May 16, 2025

1.4K

Resolution of ulcerative colitis.

Markus F Neurath1, Moritz Leppkes2

  • 1Department of Medicine 1, Translational Research Center and Kussmaul Campus for Medical Research, Deutsches Zentrum Immuntherapie (DZI), University of Erlangen-Nürnberg, Erlangen, Germany. Markus.Neurath@uk-erlangen.de.

Seminars in Immunopathology
|July 7, 2019
PubMed
Summary
This summary is machine-generated.

This review explores how the body heals ulcerative colitis (UC) at cellular and molecular levels. Understanding these mechanisms offers new therapeutic strategies for resolving chronic inflammation in UC.

Keywords:
EpitheliumIntestineLymphocytesResolution of inflammationUlcerative colitis

More Related Videos

Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model
09:11

Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model

Published on: February 14, 2021

10.5K
Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System
15:49

Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System

Published on: October 16, 2013

32.6K

Related Experiment Videos

Last Updated: Jan 22, 2026

Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis
06:19

Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis

Published on: May 16, 2025

1.4K
Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model
09:11

Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model

Published on: February 14, 2021

10.5K
Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System
15:49

Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System

Published on: October 16, 2013

32.6K

Area of Science:

  • Gastroenterology and immunology
  • Inflammatory bowel disease research
  • Mucosal healing mechanisms

Background:

  • Ulcerative colitis (UC) is a chronic inflammatory bowel disease affecting the large intestine, characterized by bloody diarrhea.
  • Its etiopathogenesis is complex, involving inflammatory alterations and requiring ongoing research for effective treatments.
  • Recent pharmaceutical advancements offer new therapeutic opportunities for managing UC.

Purpose of the Study:

  • To review the cellular and molecular factors critical for successful ulcerative colitis mucosal healing.
  • To provide novel insights into the distinct phases of mucosal repair in UC.
  • To explore molecular pathways that shift the balance from inflammation to resolution in UC.

Main Methods:

  • Literature review focusing on cellular and molecular determinants of mucosal healing in ulcerative colitis.
  • Analysis of research on epithelial restitution and adaptation to inflammation.
  • Examination of lymphocyte-driven inflammation resolution mechanisms.

Main Results:

  • Detailed description of mucosal healing phases in ulcerative colitis: initial damage, epithelial restitution, and inflammatory adaptation.
  • Identification of key cellular players, including lymphocytes, in maintaining and resolving chronic inflammation.
  • Exploration of molecular switches that transition the gut environment from an inflammatory to a resolving state.

Conclusions:

  • Successful resolution of ulcerative colitis involves intricate cellular and molecular processes during mucosal healing.
  • Understanding these mechanisms, particularly the inflammation-to-resolution transition, is crucial for developing future therapies.
  • Novel therapeutic avenues for ulcerative colitis can be paved by targeting these identified molecular and cellular determinants.