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Updated: Jan 22, 2026

Using the Threat Probability Task to Assess Anxiety and Fear During Uncertain and Certain Threat
Published on: September 12, 2014
Stria terminalis microstructure in humans predicts variability in orienting towards threat
Kristin Koller1,2, Christopher M Hatton1, Robert D Rogers1
1Wolfson Centre for Clinical and Cognitive Neuroscience, School of Psychology, Bangor University, Bangor, Gwynedd, UK.
Abstract:
Current concepts of the extended amygdala posit that basolateral to central amygdala projections mediate fear-conditioned autonomic alerting, whereas projections to the bed nucleus of the stria terminalis mediate sustained anxiety. Using diffusion tensor imaging tractography in humans, we show that microstructure of the stria terminalis correlates with an orienting bias towards threat in a saccade decision task, providing the first evidence that this circuit supports decisions guiding evaluation of threatening stimuli.
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