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Related Concept Videos

Proteomics01:33

Proteomics

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A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
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DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Drugs target macromolecules to modify ongoing cellular processes. Primary drug targets include receptors, ion channels, transporters, and enzymes.
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Hormones intricately bind to receptors on the surface or within target cells, initiating a cascade of cellular responses.
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Human civilization relies on biodiversity in many ways. Sudden changes in species biodiversity result in environmental changes that can modify weather patterns and therefore human civilizations.
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Related Experiment Video

Updated: Jan 22, 2026

Dissection of Human Retina and RPE-Choroid for Proteomic Analysis
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Target 2035: probing the human proteome.

Adrian J Carter1, Oliver Kraemer1, Matthias Zwick2

  • 1Discovery Research Coordination, Boehringer Ingelheim, 55216 Ingelheim am Rhein, Germany.

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|July 7, 2019
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Summary
This summary is machine-generated.

Biomedical research often overlooks understudied proteins crucial for disease. Developing chemical probes and antibodies for all human proteins, as Target 2035 aims to do, can unlock new understanding of health and disease, and drive drug discovery.

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Area of Science:

  • Biomedical research
  • Genomics
  • Drug discovery

Background:

  • Many human proteins, despite genetic links to disease, remain understudied by biomedical scientists.
  • Pharmacological modulators like chemical probes and antibodies are key tools for investigating protein function and therapeutic potential.

Purpose of the Study:

  • To address the gap in understanding understudied proteins and their role in human disease.
  • To facilitate the translation of genomic advances into insights on human health.
  • To accelerate the development of novel therapeutics by creating tools for the entire proteome.

Main Methods:

  • Establishing Target 2035, a global federation focused on new technology development.
  • Creating comprehensive chemogenomic libraries.
  • Developing chemical probes and functional antibodies for a wide range of proteins.

Main Results:

  • The initiative aims to provide tools for interrogating the function of most human proteins.
  • It seeks to bridge the gap between genomic data and functional understanding.
  • The project intends to catalyze the creation of innovative medicines.

Conclusions:

  • Availability of tools for understudied proteins is essential for advancing human health and disease research.
  • Target 2035's comprehensive approach to proteome tool development is critical for future biomedical breakthroughs.
  • This initiative promises to significantly impact drug discovery and the understanding of complex diseases.