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Perioperative Factors Affecting Neurologic Outcome in Infants Undergoing Surgery for Intracranial Lesion: A

Kadarapura Nanjundaiah Gopalakrishna1, Dhritiman Chakrabarti1, Nishanth Sadashiva2

  • 1Department of Neuroanaesthesia and Neurocritical Care, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bangalore, India.

World Neurosurgery
|July 7, 2019
PubMed

Insights

Mannitol use and massive blood transfusions are linked to new neurologic deficits in infants after brain tumor surgery. Reintubation and deficits also correlate with longer hospital stays.

Area of Science:

  • Pediatric Neurosurgery
  • Neurocritical Care
  • Oncology

Background:

  • Infant brain tumor surgery outcomes are influenced by perioperative factors.
  • Understanding these factors is crucial for improving patient care.
  • This study investigates perioperative variables affecting neurologic outcomes in infants undergoing brain tumor surgery.

Purpose of the Study:

  • To analyze the impact of perioperative variables on postoperative neurologic outcomes in infants undergoing brain tumor surgery.
  • To identify risk factors for new postoperative neurologic deficits (POND) and prolonged length of hospital stay (LOHS).

Main Methods:

  • Retrospective review of 40 infants undergoing craniotomy for brain tumor removal (2000-2017).
  • Data collected on preoperative, intraoperative, and postoperative factors.
  • Primary outcome: new postoperative neurologic deficit (POND); Secondary outcome: length of hospital stay (LOHS).

Main Results:

  • New-onset POND occurred in 35% of infants.
  • Mannitol use and massive blood transfusion (MBT) were associated with POND.
  • Reintubation and POND were associated with prolonged LOHS.

Conclusions:

  • Mannitol use and MBT are significant factors associated with new POND in infants undergoing brain tumor surgery.
  • Reintubation and POND are associated with prolonged LOHS.
  • Anesthetic technique, tumor location, histology, and resection extent did not significantly impact outcomes.
Abstract

Keywords:
AnesthesiaInfantNeurologic deficitsNeurosurgeryOutcomesTumor

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