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The discovery BPD (D-BPD) program: study protocol of a prospective translational multicenter collaborative study to

Gaston Ofman1,2, Mauricio T Caballero3, Damian Alvarez Paggi3,4

  • 1Department of Pediatrics, University of Alabama at Birmingham, Birmingham, USA. gofman@peds.uab.edu.

BMC Pediatrics
|July 8, 2019
PubMed

Insights

Bronchopulmonary dysplasia (BPD) affects premature infants and is a complex lung disease. The Discovery BPD program uses a multidisciplinary approach to understand BPD

Area of Science:

  • Neonatal Medicine
  • Pediatric Pulmonology
  • Genetics
  • Biostatistics

Background:

  • Premature birth is a significant global health issue, impacting over 10% of infants worldwide.
  • Bronchopulmonary dysplasia (BPD) is the most common neonatal complication of prematurity, leading to increased respiratory infections, chronic lung disease, and mortality.
  • BPD is recognized as a longitudinal disease influenced by intrauterine factors and gene-environment interactions, yet comprehensive multidisciplinary studies remain scarce.

Purpose of the Study:

  • To address the current gap in understanding Bronchopulmonary dysplasia (BPD) as a complex spectrum of disease endotypes.
  • To investigate the mechanisms, evolution, and consequences of lung diseases in preterm infants through a bedside-to-bench and bench-to-bedside approach.
  • To improve health outcomes for premature infants suffering from BPD.

Main Methods:

  • The Discovery BPD (D-BPD) Program prospectively follows a cohort of infants weighing less than 1,250g at birth until 6 years of age.
  • The program integrates detailed clinical data analysis using machine learning.
  • Genetic susceptibility and molecular translation studies are incorporated into the D-BPD program.

Main Results:

  • The D-BPD program aims to provide enhanced understanding of BPD mechanisms, evolution, and consequences.
  • This program will elucidate the multi-trait spectrum of BPD endotypes.
  • Results will contribute to improved management and treatment strategies for BPD.

Conclusions:

  • The D-BPD program offers a unique, multidisciplinary approach combining expertise from various specialists to study BPD.
  • This integrated approach examines the disease process from multiple perspectives to improve outcomes for premature infants.
  • The D-BPD program is crucial for advancing the understanding and management of Bronchopulmonary dysplasia.
Abstract

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