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Related Experiment Video

Updated: Jan 22, 2026

Methods for Detecting Cough and Airway Inflammation in Mice
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Management of Cough.

Peter G Gibson1

  • 1Department of Respiratory and Sleep Medicine, John Hunter Hospital, Newcastle, NSW, Australia; Priority Research Centre for Healthy Lungs, The University of Newcastle, Newcastle, NSW, Australia.

The Journal of Allergy and Clinical Immunology. in Practice
|July 8, 2019
PubMed
Summary

Chronic cough significantly impacts quality of life. New strategies targeting cough reflex hypersensitivity offer improved management and relief for persistent cough, with novel therapies on the horizon.

Keywords:
Chronic coughCoughCough hypersensitivityLaryngeal dysfunction

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Area of Science:

  • Respiratory Medicine
  • Neurology

Background:

  • Chronic cough causes significant quality-of-life impairment.
  • Understanding cough reflex hypersensitivity is key to effective management.
  • Current approaches focus on identifying triggers and managing cough reflex pathways.

Purpose of the Study:

  • To review current understanding and management of chronic cough.
  • To highlight the role of cough reflex hypersensitivity in persistent cough.
  • To explore novel therapeutic targets for chronic cough.

Main Methods:

  • Clinical cough assessment for patient classification and trigger identification.
  • Speech pathology for laryngeal dysfunction management.
  • Neuromodulators for central cough reflex sensitization.

Main Results:

  • Cough reflex hypersensitivity is a central concept in chronic cough.
  • Multifaceted management strategies are effective.
  • Speech pathology and neuromodulators show promise.

Conclusions:

  • Improved management strategies for chronic cough are emerging.
  • Targeting cough reflex hypersensitivity offers significant relief.
  • Novel therapies are under development for chronic cough.