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Methods for Detecting Cough and Airway Inflammation in Mice
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Cough and Eosinophilia.

Sarah Diver1, Richard J Russell1, Christopher E Brightling1

  • 1Institute for Lung Health, NIHR Leicester Biomedical Research Centre, Department of Respiratory Sciences, University of Leicester, Leicester, United Kingdom.

The Journal of Allergy and Clinical Immunology. in Practice
|July 8, 2019
PubMed
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This summary is machine-generated.

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Eosinophilic airway inflammation contributes to chronic cough in many adults. Identifying biomarkers and targeted corticosteroid therapies are key for effective treatment and improved outcomes.

Area of Science:

  • Pulmonology and Allergy

Background:

  • Eosinophilic airway inflammation affects 30-50% of chronic cough patients.
  • It is a key feature in asthma, upper airway cough syndrome, and nonasthmatic eosinophilic bronchitis.
  • While mechanisms are better understood, individual causes remain unclear.

Purpose of the Study:

  • To review the diagnosis, current/future treatments, and prognosis of chronic cough in adults with eosinophilic inflammation.
  • To highlight the role of eosinophilic inflammation in various chronic cough conditions.

Main Methods:

  • Literature review focusing on diagnosis, biomarkers, and therapeutic responses.
  • Analysis of current and emerging treatment strategies for eosinophilic airway inflammation.

Main Results:

Keywords:
AsthmaChronic coughChronic rhinosinusitisEosinophilFenoMast cellNonasthmatic eosinophilic bronchitisRhinitisUpper airway cough syndrome

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  • Inhaled corticosteroids are primary treatments for asthma and nonasthmatic eosinophilic bronchitis, with response linked to inflammation biomarkers.
  • Topical nasal corticosteroids show benefit in upper airway cough syndrome associated with allergic rhinitis and chronic rhinosinusitis with polyposis.

    • Conclusions:

    • Eosinophilic airway inflammation is a significant factor in chronic cough.
    • Biomarker-guided corticosteroid therapy is crucial for managing eosinophilic chronic cough.
    • Further research into causes and treatments is warranted.