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Updated: Jan 22, 2026

Preparation of Silica Nanoparticles Through Microwave-assisted Acid-catalysis
Published on: December 16, 2013
Electrospinning of silica nanoparticles-entrapped nanofibers for sustained gentamicin release
Xiaobo Chen1, Chun Xu2, Hong He3
1The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, 237 Luoyu Rd., Wuhan, 430079, China; Department of Orthodontics, School & Hospital of Stomatology, Wuhan University, 237 Luoyu Rd., Wuhan, 430079, China; Hospital and School of Stomatoloy, Xiamen Medical University, Xiamen, 361003, China.
Abstract:
Sustained antibiotic release is important to prevent the infections after surgical treatments such as guided tissue regeneration (GTR). Electrospinning provides a simple way to fabricate nanofibers for drug delivery. In this study, a simple method to achieve sustained antibiotic release by introducing mesoporous silica nanoparticles (MSNs)with electrospinning is developed. The nanoparticles entrapped nanofibers (MSNs-PCL) were successfully fabricated, and a sustained release of gentamicin was demonstrated. The gentamicin loaded MSNs-PCL showed strong antimicrobial effects against E. coli, indicated the sustained release behavior and the retained bioactivity. The MSNs-PCL synthesized by electrospinning method shows great potential for biomedical applications such as fabricating GTR membranes.
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