Recent developments in drug-induced movement disorders: a mixed picture
Stewart A Factor1, Pierre R Burkhard2, Stanley Caroff3
1Jean and Paul Amos Parkinson's Disease and Movement Disorders Program, Emory University School of Medicine, Atlanta, GA, USA.
The Lancet. Neurology
|July 8, 2019
Summary
Drug-induced movement disorders are common and disabling side effects of many medications. New diagnostic tools and treatments offer improved outcomes, but prevention and research into safer drugs remain crucial.
Area of Science:
- Neurology
- Pharmacology
- Movement Disorders
Background:
- Medications can cause disabling movement disorders, often underdiagnosed and mismanaged.
- Antipsychotics, particularly second-generation agents, are linked to tardive syndromes and parkinsonism, affecting vulnerable populations like children and the elderly.
Purpose of the Study:
- To review the diagnosis, management, and prevention of drug-induced movement disorders.
- To highlight recent advancements in treatment and future research directions.
Main Methods:
- Review of current literature on drug-induced movement disorders.
- Discussion of diagnostic advancements, including dopamine transporter imaging.
- Analysis of newly approved treatments for tardive syndromes.
Main Results:
- Valbenazine and deutetrabenazine represent significant advancements in tardive syndrome treatment.
- Dopamine transporter imaging aids in diagnosing drug-induced parkinsonism.
- Evidence-based management is essential for improving patient outcomes.
Conclusions:
- Despite new therapies, prevention and development of safer antipsychotics are critical.
- Further research is needed for specific tardive syndromes and drug-induced parkinsonism treatments.
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