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Can Biomarkers Guide the Use of Neoadjuvant Chemotherapy in T2 Bladder Cancer?
H Barton Grossman1, Joaquim Bellmunt2, Peter C Black3
1MD Anderson Cancer Center, University of Texas, Houston, TX, USA.
European Urology Oncology
|July 8, 2019
Summary
Neoadjuvant chemotherapy improves survival for muscle-invasive bladder cancer. Future biomarkers may help personalize treatment, guiding which patients benefit most from cisplatin-based chemotherapy before surgery.
Area of Science:
- Oncology
- Urology
- Genetics
Background:
- Current guidelines advocate cisplatin-based neoadjuvant chemotherapy for muscle-invasive bladder cancer before radical cystectomy.
- Compliance with neoadjuvant chemotherapy recommendations is suboptimal, particularly for clinical T2 bladder cancer.
- The role of radical cystectomy alone for T2 bladder cancer remains debated.
Observation:
- Novel biomarkers, including molecular phenotype and DNA damage repair gene alterations, show potential for predicting treatment response.
- Identifying predictive biomarkers could refine treatment strategies for bladder cancer.
Findings:
- Cisplatin-based neoadjuvant chemotherapy offers survival benefits for muscle-invasive bladder cancer.
- Biomarker research is crucial for optimizing patient selection for neoadjuvant chemotherapy.
Implications:
- Validated biomarkers could personalize neoadjuvant chemotherapy decisions, improving outcomes for bladder cancer patients.
- This approach may enhance treatment efficacy and reduce unnecessary toxicity.
- Further research into biomarkers is essential for advancing bladder cancer care.
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