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Utility of open surgical lung biopsy in children

Aditi Sinha1, Edmund Cheesman2, Omendra Narayan1

  • 1Department of Paediatric Respiratory Medicine, Royal Manchester Children's Hospital, Oxford Road, Manchester, M13 9WL, UK.

Pulmonary Pharmacology & Therapeutics
|July 8, 2019
PubMed

Insights

Open lung biopsy (OLB) provides a definitive diagnosis for pediatric respiratory disorders, guiding treatment and prognosis. This study found OLB to be a safe and effective diagnostic tool in children with complex lung disease.

Area of Science:

  • Pediatric Pulmonology
  • Thoracic Surgery
  • Histopathology

Background:

  • Open lung biopsy (OLB) is a key diagnostic procedure for pediatric respiratory conditions.
  • Accurate diagnosis is crucial for treatment planning and prognosis in children with complex lung disease.

Purpose of the Study:

  • To evaluate the diagnostic utility and safety of open lung biopsy in children with complex respiratory disease.

Main Methods:

  • Retrospective review of 179 open lung biopsy episodes in patients under 18 years (2006-2016).
  • Exclusion of biopsies for congenital thoracic malformations or pulmonary metastases.
  • Analysis of diagnostic yield and surgical mortality.

Main Results:

  • A definitive histological diagnosis was achieved in 35 out of 44 OLB episodes (79%) in the study cohort.
  • No deaths were directly attributed to open lung biopsy surgery.
  • The procedure was effective in diagnosing complex pediatric respiratory diseases.

Conclusions:

  • Open lung biopsy is a valuable and safe diagnostic intervention for children with complex respiratory disorders.
  • It facilitates targeted treatment strategies and provides essential prognostic information.
  • OLB aids families in planning for palliative care when necessary.
Abstract

Keywords:
Interstitial lung diseaseLung biopsyPaediatrics

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