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Genome imprinting in stem cells: A mini-review
Rasoul Godini1, Keyvan Karami2, Hossein Fallahi3
1Development and Stem Cells Program, Monash Biomedicine Discovery Institute and Department of Anatomy and Developmental Biology, Monash University, Melbourne, Victoria, 3800, Australia.
Gene Expression Patterns : GEP
|July 8, 2019
Summary
Genomic imprinting, essential for development, can be disrupted in induced pluripotent stem (iPS) cells. Maintaining imprinting marks in iPS cells is crucial for safe regenerative medicine applications.
Area of Science:
- Epigenetics
- Genomic imprinting
- Stem cell biology
Background:
- Genomic imprinting silences one parental allele, crucial for normal development.
- Dysregulation of imprinted genes causes developmental abnormalities.
- Epigenetic reprogramming in induced pluripotent stem (iPS) cells requires erasure of imprinting marks.
Purpose of the Study:
- To investigate the imprinting status in iPS cells.
- To address contradictory reports on imprinting marks in iPS cell genomes.
- To compare imprinting loci differences between iPS and embryonic stem (ES) cells.
Main Methods:
- Analysis of imprinting marks in iPS cell genomes.
- Comparison of imprinting loci between iPS and ES cells.
- Evaluation of epigenetic reprogramming efficiency.
Main Results:
- Contradictory findings exist regarding imprinting mark status in iPS cells.
- Subtle differences in imprinting loci are observed between iPS and ES cells.
- Imprinting dysregulation may impact iPS cell therapeutic potential.
Conclusions:
- The imprinting status in iPS cells requires further clarification.
- Imprinting locus variations may affect the utility of patient-derived iPS cells.
- Ensuring imprinting fidelity is vital for regenerative medicine.
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