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Clinical Profile and Short Term Outcome of Children with Neutropenia

Akanksha Mahajan1, Virendra Kumar2, Sangeeta Pahuja Sindhwani3

  • 1Department of Pediatrics, Lady Hardinge Medical College and associated Kalawati Saran Children's Hospital, New Delhi, India. a.k.a.mahajan91@gmail.com.

Indian Journal of Pediatrics
|July 8, 2019
PubMed

Insights

Acute transient neutropenia in children is often caused by febrile illnesses like dengue, typically resolving within 3 days. Most children experienced short hospital stays without complications, highlighting the generally favorable short-term outcomes.

Area of Science:

  • Pediatrics
  • Hematology
  • Infectious Diseases

Background:

  • Neutropenia, defined as an absolute neutrophil count less than 1500/mm³.
  • Observational study in a pediatric hospital setting.

Purpose of the Study:

  • To investigate the clinical characteristics and short-term outcomes of neutropenia in hospitalized children.
  • To identify common etiologies and associated conditions.

Main Methods:

  • Inclusion of 77 children (1 month to 18 years) with neutropenia, excluding those with known immunodeficiency or malignancy.
  • Etiological investigations based on clinical presentation.
  • Follow-up for 4 weeks or until discharge to analyze neutropenia duration, hospital stay, and complications.

Main Results:

  • Acute transient neutropenia observed, with a median duration of 3 days in younger patients.
  • Dengue fever identified as the most common cause.
  • Median hospital stay was 8 days; 68.8% had associated thrombocytopenia; 3 developed complications (sepsis, shock).

Conclusions:

  • Acute febrile illnesses, including dengue, enteric fever, and malaria, are primary causes of pediatric neutropenia.
  • Mild neutropenia in over 50% of children resulted in short admissions (5-8 days) without complications.
Abstract

Keywords:
DengueFebrile illnessNeutropeniaNon malignant

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