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Dosimetry for Cell Irradiation using Orthovoltage 40-300 kV X-Ray Facilities
Published on: February 20, 2021
Comparison of the Stability of Poly-γ-Glutamate Hydrogels Prepared by UV and γ-Ray Irradiation
Sang-Joon Park1, Hiroshi Uyama2, Mi-Sun Kwak1
1Department of Bio and Fermentation Convergence Technology, BK21 PLUS Project, Kookmin University, Seoul 02707, Republic of Korea.
Abstract:
Poly-γ-glutamate (γ-PGA) has various applications due to its desirable characteristics in terms of safety and biodegradability. Previous studies have been conducted on γ-PGA hydrogels produced by γ-ray irradiation, but these hydrogels have proved unstable in solutions. This study was conducted to enable the γ-PGA hydrogel to maintain a stable form in solutions. The γ-PGA mixture for UV-irradiation was prepared with a cross-linker (N,N,N-trimethyl-3-[(2- methylacryloyl)amino]propan-1-aminium). Both γ-PGA hydrogels' characteristics, including stability in solutions, were examined. The UV-irradiated γ-PGA hydrogel maintained a stable form during the nine weeks of the study, but the γ-ray irradiated hydrogel dissolved after one week.
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