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Golden Opportunity: A Clickable Azide-Functionalized [Au25(SR)18]- Nanocluster Platform for Interfacial Surface
Praveen N Gunawardene1, John F Corrigan1, Mark S Workentin1
1Department of Chemistry and the Centre for Advanced Materials and Biomaterials Research , The University of Western Ontario , London , Ontario N6A 5B7 , Canada.
Journal of the American Chemical Society
|July 9, 2019
Summary
Researchers developed a new gold nanocluster platform with azide groups for surface modification. This breakthrough enables direct synthesis and versatile post-assembly functionalization of these atomically precise nanomaterials.
Area of Science:
- Nanomaterials Science
- Surface Chemistry
- Organic Chemistry
Background:
- Atomically precise gold nanoclusters are promising but lack direct synthesis and surface chemistry platforms.
- Existing nanocluster systems present challenges for tailored interfacial modifications.
Purpose of the Study:
- To develop a novel, surface-reactive gold nanocluster platform.
- To enable direct synthesis and facile post-assembly surface functionalization of gold nanoclusters.
Main Methods:
- Synthesis of [Au25(SCH2CH2-p-C6H4-N3)18]- nanoclusters with surface-appended azide moieties.
- Structural characterization using single-crystal X-ray crystallography, mass spectrometry, and various spectroscopies (UV-Vis, IR, NMR).
- Demonstration of strain-promoted alkyne-azide cycloaddition (SPAAC) with cyclooctyne.
Main Results:
- Successfully synthesized and structurally confirmed the [Au25(SCH2CH2-p-C6H4-N3)18]- nanocluster.
- All surface azide groups were reactive towards SPAAC chemistry.
- Established a new platform for post-assembly surface modification of gold nanoclusters.
Conclusions:
- The developed nanocluster platform offers a direct route for synthesis and versatile surface chemistry.
- This breakthrough enables tailored functionalization of prominent gold nanocluster systems.
- Opens new avenues for advanced applications of atomically precise nanoclusters through controlled surface engineering.
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