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Updated: Jan 22, 2026

Preparation and In Vitro Characterization of Dendrimer-based Contrast Agents for Magnetic Resonance Imaging
Published on: December 4, 2016
Fluorinated MRI contrast agents and their versatile applications in the biomedical field
Emilie Hequet1, Céline Henoumont1, Robert N Muller1,2
1General, Organic & Biomedical Chemistry Unit, Nuclear Magnetic Resonance (NMR) & Molecular Imaging Laboratory, University of Mons (UMONS), Avenue Victor Maistriau 19, 7000 Mons, Belgium.
Abstract:
MRI has been recognized as one of the most applied medical imaging techniques in clinical practice. However, the presence of background signal coming from water protons in surrounding tissues makes sometimes the visualization of local contrast agents difficult. To remedy this, fluorine has been introduced as a reliable perspective, thanks to its magnetic properties being relatively close to those of protons. In this review, we aim to give an overall description of fluorine incorporation in contrast agents for MRI. The different kinds of fluorinated probes such as perfluorocarbons, fluorinated dendrimers, polymers and paramagnetic probes will be described, as will their imaging applications such as chemical exchange saturation transfer (CEST) imaging, physico-chemical changes detection, drug delivery, cell tracking and inflammation or tumors detection.
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