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Updated: Jan 22, 2026

Acute Myocardial Infarction in Rats
Published on: February 16, 2011
Door-to-Needle Time in Myocardial Infarction: Small Steps, Huge Dividends
Vivek Chauhan1, Bhagwan Das Negi2, Gurudutt Sharma2
1IGMC Shimla, Himachal Pradesh, India.
Insights
Implementing a fast-track protocol in the emergency department significantly reduced door-to-needle time for ST-elevation myocardial infarction (STEMI) patients. This zero-cost intervention saves critical minutes, improving outcomes for acute coronary syndrome.
Area of Science:
- Cardiology
- Emergency Medicine
- Health Services Research
Background:
- Prehospital delay in acute coronary syndrome (ACS) is a significant issue, with a Himachal Pradesh registry reporting 780 minutes.
- Each hour of delay in door-to-needle time increases the hazard ratio of death by 20% in ST-elevation myocardial infarction (STEMI) patients.
- Efficient emergency department (ED) protocols are crucial for timely reperfusion therapy.
Purpose of the Study:
- To evaluate the impact of a fast-track protocol on door-to-needle time in STEMI patients.
- To assess the cost-effectiveness and time-saving benefits of implementing a streamlined ED process.
- To compare door-to-needle times between retrospective and prospective patient groups.
Main Methods:
- Retrospective (group 1) and prospective (group 2) analysis of 63 STEMI patients each.
- Implementation of a zero-cost fast-track protocol in the emergency department.
- Measurement of door-to-needle times before and after protocol implementation.
Main Results:
- The fast-track protocol significantly reduced door-to-needle time by 63 minutes for STEMI patients.
- Performing thrombolysis in the ED, rather than CCU, saved an additional 33 minutes.
- The protocol was implemented at zero cost to the hospital.
Conclusions:
- A fast-track protocol is an effective, zero-cost strategy to reduce door-to-needle time in STEMI.
- Streamlining ED processes for thrombolysis improves efficiency and potentially patient outcomes.
- Reducing delays in STEMI management is critical for mitigating mortality risk.
Abstract:
The Himachal Pradesh acute coronary syndrome registry highlighted a prehospital delay of 780 min. Additional door-to-needle time delay by 1 h increases the hazard ratio of death by 20%. We conducted a retrospective (group 1) and a prospective (group 2) analysis of 63 patients each to measure the impact of a fast-track protocol in the emergency department (ED) on the door-to-needle time in ST-elevation myocardial infarction (STEMI). The fast-track protocol involved zero cost to the hospital and saved 63 precious door-to-needle minutes for patients with STEMI. Thrombolysis in ED can save 33 precious minutes wasted in shifting patients to the coronary care unit.
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