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Targeting angiogenesis for patients with unresectable malignant pleural mesothelioma

Anne Tsao1, Takashi Nakano2, Anna K Nowak3

  • 1Department of Thoracic and Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Seminars in Oncology
|July 9, 2019
PubMed

Insights

Malignant pleural mesothelioma (MPM) is a growing global health concern. This review explores targeting angiogenesis, a key process in cancer growth, as a promising therapeutic strategy for unresectable MPM.

Area of Science:

  • Oncology
  • Pulmonology

Background:

  • Malignant pleural mesothelioma (MPM) is a serious asbestos-related cancer.
  • Its prevalence is expected to increase globally due to long latency periods.
  • Unresectable MPM has limited treatment options and a poor prognosis.

Purpose of the Study:

  • To review the scientific rationale for targeting angiogenesis in unresectable MPM.
  • To analyze recent clinical trial results of antiangiogenic agents in MPM management.

Main Methods:

  • Review of scientific literature and clinical trial data.
  • Analysis of therapeutic targets including angiogenesis, immune checkpoints, and mesothelin.
  • Focus on first-line treatment strategies combining antiangiogenic agents with chemotherapy.

Main Results:

  • Angiogenesis is a key therapeutic target in MPM.
  • Several antiangiogenic agents (bevacizumab, nintedanib, cediranib) are under investigation.
  • Combination therapy with chemotherapy shows potential in recent trials.

Conclusions:

  • Targeting angiogenesis offers a promising avenue for treating unresectable MPM.
  • Further clinical evaluation of antiangiogenic agents is warranted.
  • Combination therapies may improve outcomes for MPM patients.
Keywords:
AngiogenesisAsbestosMalignant pleural mesothelioma

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