Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Coagulation01:06

Coagulation

1.3K
Colloidal solids are solid particles suspended in solution. They are usually negatively charged, attracting a compact primary layer of positively charged ions, which attract more counterions to form an electrical double layer. Electrostatic repulsion between the charged double layers prevents the particles from colliding, stabilizing the colloids. These solids are often undesirable because they can contain toxins that are difficult to remove. Coagulation is a technique that helps aggregate and...
1.3K
Coagulation01:09

Coagulation

9.8K
The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
9.8K
Autoimmune Disorders01:29

Autoimmune Disorders

1.5K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
1.5K
Skin Cancer01:30

Skin Cancer

5.8K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
5.8K
Sensory Functions of the Skin01:16

Sensory Functions of the Skin

8.0K
The skin is the largest organ of the human body and plays a crucial role in our sensory perception. It contains a vast network of sensory receptors that contribute to the skin's protective function by perceiving physical, biological, and environmental cues and generating relevant responses.
There are two main categories of receptors on the skin: capsulated and non-capsulated. The non-capsulated ones are mainly the pain receptors. The capsulated ones can be further categorized based on the...
8.0K
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

5.2K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
5.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Real-Life Effectiveness and Safety of Lebrikizumab in Elderly Patients with Atopic Dermatitis: A Multicenter Study.

Clinical and experimental dermatology·2026
Same author

Spring-assisted cranioplasty for sagittal synostosis: long-term clinical and patient-reported outcomes : Ten-year outcomes of spring-assisted cranioplasty for isolated sagittal synostosis: a single-institution cohort study.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery·2026
Same author

Tumor-field predominant bullous pemphigoid in a patient with metastatic melanoma.

Clinical and experimental dermatology·2026
Same author

Mechanobiological modeling of bone healing in mandibular reconstruction: a comparative study of fixation strategies.

Computer methods in biomechanics and biomedical engineering·2026
Same author

Oral isotretinoin and acne clearance: the role of daily dosage in a real-world clinical setting.

Italian journal of dermatology and venereology·2026
Same author

<i>Letter:</i> Unexpected Hair Regrowth in Long-Standing Alopecia Universalis During Dupilumab Therapy for Chronic Rhinosinusitis with Nasal Polyps.

Dermatitis : contact, atopic, occupational, drug·2026

Related Experiment Video

Updated: Jan 22, 2026

A Rapid, Simple, and Standardized Homogenization Method to Prepare Antigen/Adjuvant Emulsions for Inducing Experimental Autoimmune Encephalomyelitis
05:44

A Rapid, Simple, and Standardized Homogenization Method to Prepare Antigen/Adjuvant Emulsions for Inducing Experimental Autoimmune Encephalomyelitis

Published on: December 9, 2022

4.4K

Coagulation and Skin Autoimmunity.

Massimo Cugno1,2, Alessandro Borghi3, Simone Garcovich4

  • 1Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, Milan, Italy.

Frontiers in Immunology
|July 9, 2019
PubMed
Summary
This summary is machine-generated.

Immune, inflammation, and coagulation pathways are interconnected in autoimmune skin diseases like chronic spontaneous urticaria and bullous pemphigoid. This review explores their cross-talk and implications for treatment.

Keywords:
angioedemaatopic dermatitisautoimmunitybullous pemphigoidcoagulationdermatitis herpetiformispsoriasisurticaria

More Related Videos

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
04:39

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

2.5K
Assessment of Plasma Coagulation on Liver Tissue in a Large Animal Model In Vivo
06:23

Assessment of Plasma Coagulation on Liver Tissue in a Large Animal Model In Vivo

Published on: August 4, 2018

9.2K

Related Experiment Videos

Last Updated: Jan 22, 2026

A Rapid, Simple, and Standardized Homogenization Method to Prepare Antigen/Adjuvant Emulsions for Inducing Experimental Autoimmune Encephalomyelitis
05:44

A Rapid, Simple, and Standardized Homogenization Method to Prepare Antigen/Adjuvant Emulsions for Inducing Experimental Autoimmune Encephalomyelitis

Published on: December 9, 2022

4.4K
Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
04:39

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

2.5K
Assessment of Plasma Coagulation on Liver Tissue in a Large Animal Model In Vivo
06:23

Assessment of Plasma Coagulation on Liver Tissue in a Large Animal Model In Vivo

Published on: August 4, 2018

9.2K

Area of Science:

  • Dermatology
  • Immunology
  • Hematology

Background:

  • Autoimmune and immune-mediated skin diseases involve simultaneous activation of the immune system, inflammation, and coagulation.
  • Pro-inflammatory cytokines (e.g., IL-6, TNF-α) upregulate tissue factor, initiating coagulation.
  • Coagulation proteases activate protease-activated receptors, further promoting inflammation.

Purpose of the Study:

  • To review the intricate relationships among the immune system, inflammation, and coagulation in specific skin disorders.
  • To focus on chronic spontaneous urticaria (CSU), angioedema, and bullous pemphigoid (BP) regarding these interactions.

Main Methods:

  • Review of existing literature on the interplay between immunity, inflammation, and coagulation in selected skin diseases.
  • Analysis of clinical relevance and investigation of these relationships in CSU, angioedema, and BP.

Main Results:

  • Elevated markers of thrombin generation, fibrinolysis, and inflammation observed during flares of CSU, angioedema, and active BP.
  • Marker levels normalize during remission.
  • Coagulation activation is primarily local in CSU and angioedema, but both local and systemic in BP.
  • Bullous pemphigoid is associated with an increased thrombotic risk.

Conclusions:

  • The cross-talk among immune, inflammatory, and coagulation pathways amplifies and sustains disease activity in autoimmune skin conditions.
  • The prothrombotic state in these diseases, especially BP, warrants consideration for anticoagulant therapy, particularly with co-existing cardiovascular risk factors.