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Related Concept Videos

Arteries of the Head and Neck01:26

Arteries of the Head and Neck

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The human body's intricate network of arteries ensures that every organ system receives the necessary oxygen and nutrients for optimal function. The arterial network in the head and neck region is particularly complex, providing vital blood flow to the brain, eyes, and other critical structures. Prominent arteries in this region include the internal carotid arteries and the vertebral arteries.
The internal carotid arteries supply blood to the anterior portion of the cerebrum. They enter the...
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Veins of Head and Neck01:19

Veins of Head and Neck

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The blood drainage from the head and neck is primarily managed by three pairs of veins: the external jugular, internal jugular, and vertebral veins. The external jugular veins drain superficial scalp and face structures, passing over the sternocleidomastoid muscles to empty into the subclavian veins.
On the other hand, the vertebral veins, unlike their arterial counterparts, are not primarily responsible for brain drainage. Instead, they drain the cervical vertebrae, spinal cord, and some small...
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Muscles of the Anterior Neck01:26

Muscles of the Anterior Neck

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The anterior neck muscles are the group of muscles covering the front part of the neck. These muscles are classified into three subgroups. The first one is the superficial muscles, the most visible muscles in the front of the neck. It includes the platysma and sternocleidomastoid. The second group is the suprahyoid muscles, located above the hyoid bone. This group comprises the digastric, mylohyoid, geniohyoid, and stylohyoid. Lastly, the infrahyoid muscles are found below the hyoid bone and...
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5-Number Summary01:04

5-Number Summary

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In a dataset, the 5-number summary includes the minimum data value, the data value of the first quartile, the median data value or data value of the second quartile, the data value of the third quartile, and the maximum data value. These 5 data values can be visualized as a box and whisker plot.
In a box plot, the minimum and maximum data values represent the lower and upper whiskers in the graph, and the median is designated as the center of the box in the chart. The first quartile and third...
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The Cell Cycle Control System01:28

The Cell Cycle Control System

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The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and...
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The Cell Cycle Control System02:11

The Cell Cycle Control System

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The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
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Related Experiment Video

Updated: Jan 22, 2026

A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma
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A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma

Published on: January 5, 2017

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Sorting Nexin 5 Controls Head and Neck Squamous Cell Carcinoma Progression by Modulating FBW7.

Jinyang Cai1, Ming Sun1, Bin Hu2

  • 1Philips Institute for Oral Health Research, School of Dentistry and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA.

Journal of Cancer
|July 9, 2019
PubMed
Summary
This summary is machine-generated.

Sorting Nexin 5 (SNX5) promotes head and neck squamous cell carcinoma (HNSCC) progression by inhibiting the degradation of oncoproteins. Targeting SNX5 may offer a new therapeutic strategy for HNSCC patients.

Keywords:
FBW7HNSCCSNX5oncoproteinubiquitination

More Related Videos

Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics
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Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics

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Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma
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Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma

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Related Experiment Videos

Last Updated: Jan 22, 2026

A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma
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A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma

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Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics
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Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics

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Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma
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Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma

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Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Head and neck squamous cell carcinoma (HNSCC) is a prevalent cancer with stagnant survival rates.
  • Novel molecular targets are crucial for improving HNSCC treatment outcomes.

Purpose of the Study:

  • To identify and characterize novel molecular regulators of HNSCC progression.
  • To investigate the role of Sorting Nexin 5 (SNX5) as a potential therapeutic target in HNSCC.

Main Methods:

  • Analysis of HNSCC patient data from The Cancer Genome Atlas (TCGA).
  • In vitro studies using HNSCC cell lines to assess SNX5 function.
  • In vivo xenograft mouse models to evaluate tumor growth.
  • Co-immunoprecipitation assays to study protein interactions.

Main Results:

  • SNX5 expression is significantly elevated in HNSCC tissues and correlates with poor prognosis.
  • SNX5 knockdown reduces HNSCC cell proliferation and tumor growth in vivo.
  • SNX5 interacts with and inhibits the tumor suppressor FBW7, leading to decreased degradation of oncoproteins (c-Myc, NOTCH1, Cyclin E1).

Conclusions:

  • SNX5 acts as an oncogene in HNSCC by disrupting FBW7-mediated oncoprotein degradation.
  • SNX5 represents a promising novel therapeutic target for HNSCC treatment.