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Updated: Jan 22, 2026
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A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma
Published on: January 5, 2017
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Sorting Nexin 5 Controls Head and Neck Squamous Cell Carcinoma Progression by Modulating FBW7
Jinyang Cai1, Ming Sun1, Bin Hu2
1Philips Institute for Oral Health Research, School of Dentistry and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA.
Journal of Cancer
|July 9, 2019
Summary
Sorting Nexin 5 (SNX5) promotes head and neck squamous cell carcinoma (HNSCC) progression by inhibiting the degradation of oncoproteins. Targeting SNX5 may offer a new therapeutic strategy for HNSCC patients.
Area of Science:
- Oncology
- Molecular Biology
- Cancer Research
Background:
- Head and neck squamous cell carcinoma (HNSCC) is a prevalent cancer with stagnant survival rates.
- Novel molecular targets are crucial for improving HNSCC treatment outcomes.
Purpose of the Study:
- To identify and characterize novel molecular regulators of HNSCC progression.
- To investigate the role of Sorting Nexin 5 (SNX5) as a potential therapeutic target in HNSCC.
Main Methods:
- Analysis of HNSCC patient data from The Cancer Genome Atlas (TCGA).
- In vitro studies using HNSCC cell lines to assess SNX5 function.
- In vivo xenograft mouse models to evaluate tumor growth.
- Co-immunoprecipitation assays to study protein interactions.
Main Results:
- SNX5 expression is significantly elevated in HNSCC tissues and correlates with poor prognosis.
- SNX5 knockdown reduces HNSCC cell proliferation and tumor growth in vivo.
- SNX5 interacts with and inhibits the tumor suppressor FBW7, leading to decreased degradation of oncoproteins (c-Myc, NOTCH1, Cyclin E1).
Conclusions:
- SNX5 acts as an oncogene in HNSCC by disrupting FBW7-mediated oncoprotein degradation.
- SNX5 represents a promising novel therapeutic target for HNSCC treatment.
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