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Expression of WDR79 is associated with TP53 mutation and poor prognosis in surgically resected non-small cell lung

Jinwu Peng1,2,3, Yuting Zhan4, Juan Feng4

  • 1Department of Pathology, Xiangya Basic Medical School, Central South University, Changsha 410013, Hunan, China.

Journal of Cancer
|July 9, 2019
PubMed

Insights

WD repeat protein 79 (WDR79) expression is elevated in non-small cell lung cancer (NSCLC) and linked to TP53 mutations. High WDR79 levels indicate poor prognosis and serve as a potential biomarker for NSCLC patients.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Non-small cell lung cancer (NSCLC) poses a significant global health challenge.
  • WD repeat protein 79 (WDR79), a conserved natural antisense transcript to the TP53 gene, is implicated in various cancers.
  • The association between WDR79 expression, TP53 mutations, and clinical outcomes in NSCLC remains uninvestigated.

Purpose of the Study:

  • To investigate the relationship between WDR79 protein expression and mutant p53 (mtp53) in NSCLC.
  • To analyze the correlation between WDR79 expression and clinicopathological features in NSCLC patients.
  • To determine the prognostic significance of WDR79 expression in surgically resected NSCLC.

Main Methods:

  • Immunohistochemistry was employed to assess WDR79 and mtp53 expression in NSCLC tissues and non-cancerous lung tissues.
  • Spearman's rank correlation analysis was used to evaluate the association between WDR79 and mtp53 expression.
  • Kaplan-Meier survival analysis and multivariate Cox regression were performed to assess prognostic implications.

Main Results:

  • Positive WDR79 (58.8%) and mtp53 (48.1%) expression were significantly higher in NSCLC compared to controls.
  • WDR79 expression was significantly associated with lymph node metastasis.
  • A positive correlation was found between WDR79 and mtp53 expression (r=0.212, P=0.014).

Conclusions:

  • Positive WDR79 expression is linked to TP53 mutations in NSCLC.
  • WDR79 expression, alone or with mtp53, correlates with poorer overall survival in NSCLC patients.
  • WDR79 serves as an independent prognostic biomarker for predicting poor outcomes in surgically resected NSCLC.
Keywords:
Non-small cell lung cancerTP53WDR79mutantprognosis

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