Related Experiment Video

Updated: Jan 22, 2026

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination
09:38

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination

Published on: September 12, 2016

12.7K

Blocking interleukin-6 trans-signaling protects against renal fibrosis by suppressing STAT3 activation

Wei Chen1, Hui Yuan1, Wenmin Cao1

  • 1Department of Urology, Drum Tower Hospital, Medical School of Nanjing University, Institute of Urology, Nanjing University, Nanjing, Jiangsu, China.

Theranostics
|July 9, 2019
PubMed

Insights

Targeting interleukin-6 (IL-6) trans-signaling with Fc-gp130 effectively reduced renal fibrosis in mouse models. This approach offers a promising new therapeutic strategy for kidney disease by inhibiting key fibrotic pathways.

Area of Science:

  • Nephrology
  • Immunology
  • Molecular Biology

Background:

  • Renal fibrosis is an irreversible consequence of chronic kidney disease with limited treatment options.
  • Elevated interleukin-6 (IL-6) signaling is implicated in the progression of renal fibrosis.

Purpose of the Study:

  • To investigate the therapeutic potential of blocking IL-6 trans-signaling in renal fibrosis.
  • To evaluate the efficacy of Fc-gp130, an IL-6 trans-signaling inhibitor, in preclinical models of kidney fibrosis.

Main Methods:

  • Utilized unilateral ureteral occlusion (UUO) and ischemia-reperfusion (IR) mouse models to induce renal fibrosis.
  • Administered Fc-gp130 to block IL-6 trans-signaling and assessed its impact on fibrotic markers, inflammation, and cellular signaling.
  • Conducted in vitro experiments using fibroblasts to elucidate the mechanism of action.

Main Results:

  • Fc-gp130 treatment significantly attenuated renal fibrosis, reducing tubular atrophy and extracellular matrix deposition in UUO and IR models.
  • Blockade of IL-6 trans-signaling decreased inflammation, immune cell infiltration, and STAT3 phosphorylation, a key mediator of fibrosis.
  • Fc-gp130 inhibited TGF-β1-induced STAT3 phosphorylation in fibroblasts, demonstrating a direct cellular effect.

Conclusions:

  • IL-6 trans-signaling plays a critical role in the pathogenesis of renal fibrosis.
  • Targeting IL-6 trans-signaling with Fc-gp130 represents a novel and effective therapeutic strategy for treating renal fibrosis and related kidney diseases.
Keywords:
Fc-gp130IL-6 trans-signalingSTAT3chronic kidney diseaserenal fibrosis

More Related Videos

Direct Drug Delivery to Kidney via the Renal Artery11:18

Direct Drug Delivery to Kidney via the Renal Artery

Published on: April 17, 2021

8.1K
Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation11:49

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation

Published on: May 2, 2013

16.6K

Related Concept Videos

Endocrine Signaling01:45

Endocrine Signaling

Endocrine cells produce hormones to communicate with remote target cells found in other organs. The hormone reaches these distant areas using the circulatory system. This exposes the whole organism to the hormone but only those cells expressing hormone receptors or target cells are affected. Thus, endocrine signaling induces slow responses from its target cells but these effects also last longer.
67.9K
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
740
Zones of Protection01:16

Zones of Protection

In power systems, the entire setup is divided into protective zones to isolate faults and protect the rest of the network. These zones include generators, transformers, buses, transmission lines, distribution lines, and motors. Each zone can be visualized as a separate room in a house, with each room protected by its own circuit breaker.
Protective zones are defined by closed dashed lines, containing one or more components. A key characteristic of these zones is the strategic placement of...
770
Protection of Alcohols02:31

Protection of Alcohols

This lesson delves into the concept of protection and deprotection of a functional group fundamental to synthetic organic chemistry. These phenomena are explained in the context of aliphatic and aromatic alcohols.
Protection
It defines a protecting group as the masking agent to make the more reactive species inert to a given set of conditions. This concept is depicted via the illustration of liquid flow through different outlets in an assembly of pipes. The analogy helps to understand the role...
8.0K
Protecting Self-Esteem01:27

Protecting Self-Esteem

Self-esteem, a central component of psychological well-being, is actively maintained through various cognitive and behavioral strategies. Individuals employ specific mechanisms to preserve a positive self-concept and mitigate threats to their self-worth, particularly in contexts involving social evaluation or personal feedback. Four primary techniques are commonly used to sustain self-esteem.Manipulating AppraisalsOne prominent strategy involves manipulating appraisals from others. Individuals...
201
Radial System Protection01:23

Radial System Protection

Radial systems employ time-delay overcurrent relays to reduce load interruptions. When a fault occurs, the nearest breaker opens first, while upstream breakers remain closed due to longer delay settings. This approach ensures minimal disruption to the rest of the system.
In a radial system with a fault downstream of the third breaker, ideally, only the third breaker will open, isolating the fault and interrupting the load connected beyond it. The second breaker has a longer delay setting,...
425