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Automated 3D Optical Coherence Tomography to Elucidate Biofilm Morphogenesis Over Large Spatial Scales
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Multi-scale and -contrast sensorless adaptive optics optical coherence tomography.

Myeong Jin Ju1,2, Destiny Hsu1, Ji Hoon Kwon1

  • 1Department of Engineering Science, Simon Fraser University, Burnaby, Canada.

Quantitative Imaging in Medicine and Surgery
|July 9, 2019
PubMed
Summary
This summary is machine-generated.

This study introduces a new multi-contrast sensorless adaptive optics optical coherence tomography angiography (MSC-SAO-OCTA) system. It enables high-resolution imaging of retinal capillaries and retinal pigment epithelium (RPE) for better disease investigation.

Keywords:
Optical coherence tomography (OCT)adaptive opticsangiographyophthalmologypolarimetric imagingretina

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Area of Science:

  • Ophthalmic imaging
  • Biomedical optics
  • Retinal imaging technology

Background:

  • High-resolution visualization of the retinal microvasculature and retinal pigment epithelium (RPE) is clinically valuable for retinal health.
  • The RPE and microvasculature are crucial for maintaining retinal health and metabolic activity.

Purpose of the Study:

  • To develop a novel multi-contrast sensorless adaptive optics optical coherence tomography (MSC-SAO-OCT) system.
  • To enable high-resolution imaging of RPE pigment and retinal capillary flow using OCT angiography (OCTA).

Main Methods:

  • Integration of polarization diversity detection (PDD) into MSC-SAO-OCT.
  • Utilizing transmissive deformable optical elements for aberration correction based on image quality.
  • Performing MSC-SAO-OCTA imaging at multiple fields-of-view (FOVs) with adjustable numerical aperture (NA).

Main Results:

  • Demonstrated clinical feasibility of the MSC-SAO-OCTA system for in vivo imaging.
  • Acquired high-resolution images of retinal flow and RPE structure in healthy and pathological human eyes.
  • Successfully imaged both large and small fields-of-view.

Conclusions:

  • The developed MSC-SAO-OCTA system allows for sophisticated investigation of retinal pathologies in vivo.
  • Enables high-resolution imaging of retinal vasculature and characterization of RPE topology and deformation.
  • Potential for detecting and analyzing subtle RPE layer deformations with a single instrument.