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Related Concept Videos

Brain Imaging01:14

Brain Imaging

681
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
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Aging01:26

Aging

636
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
636
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

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The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
3.4K
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

192
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

231
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
231

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Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans
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Imaging the aged brain: pertinence and methods.

Hannah Humayun1, Junjie Yao1

  • 1Photoacoustic Imaging Laboratory, Department of Biomedical Engineering, Duke University, Durham, NC, USA.

Quantitative Imaging in Medicine and Surgery
|July 9, 2019
PubMed
Summary
This summary is machine-generated.

As people age, brain function declines, making brain imaging crucial. This paper explores advanced imaging techniques for understanding the aging brain and age-related diseases.

Keywords:
Brain imagingagingmagnetic resonance imaging (MRI)neuroscienceneurovascular couplingoptical imagingpositron emission tomography

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Area of Science:

  • Neuroscience
  • Gerontology
  • Medical Imaging

Background:

  • Global populations are aging rapidly, leading to increased challenges in cognitive functions like working memory and processing speed.
  • Age-related diseases are prevalent, highlighting the need to understand brain changes in older adults.
  • Existing brain imaging studies have not fully explored the structural and functional differences in healthy and diseased aged brains.

Purpose of the Study:

  • To discuss the importance and challenges of imaging the aged brain.
  • To analyze various imaging modalities and their applications for studying brain aging.
  • To envision potential breakthroughs in neuroimaging for the aging population.

Main Methods:

  • Review of current and emerging brain imaging technologies, including optical imaging, magnetic resonance imaging (MRI), and photoacoustic tomography.
  • Analysis of the unique advantages and limitations of each imaging method in the context of the aged brain.
  • Exploration of structural, functional, blood flow, and neurovascular coupling differences in aging brains.

Main Results:

  • Aging impacts cognitive functions, necessitating specialized imaging approaches.
  • Diverse imaging techniques offer unique insights into brain structure and function across the lifespan.
  • Significant differences exist in aged brains, both healthy and diseased, requiring deeper investigation.

Conclusions:

  • Imaging the aged brain is critical for understanding cognitive decline and age-related diseases.
  • Advanced imaging modalities hold promise for novel discoveries in gerontology and neuroscience.
  • Further research using these techniques can lead to significant breakthroughs in brain health for aging populations.