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Cell-free DNA (cfDNA) levels increase with age in rats and significantly rise in older rats with benign prostatic hyperplasia (BPH), indicating enhanced cell death during BPH development.

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Area of Science:

  • Biomedical Science
  • Molecular Biology
  • Urology

Background:

  • Aging is associated with altered physiological processes.
  • Benign prostatic hyperplasia (BPH) is a common condition in aging men.
  • Cell-free DNA (cfDNA) in blood can serve as a biomarker for cellular processes.

Purpose of the Study:

  • To investigate age-related changes in cfDNA levels.
  • To examine cfDNA dynamics in young and old rats with experimentally induced benign prostatic hyperplasia (BPH).

Main Methods:

  • Wistar rats (young and old) were divided into intact and testosterone-induced BPH groups.
  • BPH was induced via castration and testosterone ester administration.
  • Blood cfDNA levels, body weight, prostate weight, prostate index (PI), and testosterone levels were measured.

Main Results:

  • Intact old rats had higher cfDNA than young rats.
  • In BPH groups, young rats showed decreased cfDNA, while old rats exhibited significantly increased cfDNA.
  • Old rats with BPH had greater body and prostate weights and increased PI compared to young rats with BPH.
  • Apoptosis markers (inferred from cfDNA) increased in old rats with BPH, but not significantly in young rats.

Conclusions:

  • Aging exacerbates cell death processes during BPH development.
  • cfDNA levels may serve as an indicator of enhanced apoptosis in aging individuals with BPH.
  • Age is a critical factor influencing the response to BPH induction and associated cellular changes.