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Does active rheumatoid arthritis affect intestinal iron absorption?

H P Benn1, J Drews, G Randzio

  • 1Second Department of Internal Medicine, University of Kiel, FRG.

Annals of the Rheumatic Diseases
|February 1, 1988
PubMed
Summary
This summary is machine-generated.

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In rheumatoid arthritis patients, iron absorption is linked to iron stores. Defective absorption and intestinal issues are not the cause of anemia in this condition.

Area of Science:

  • Rheumatology
  • Hematology
  • Gastroenterology

Background:

  • Anemia is a common complication in rheumatoid arthritis (RA).
  • Defective iron absorption is a suspected cause of anemia in RA patients.
  • Iron metabolism plays a crucial role in overall health and disease states.

Purpose of the Study:

  • To investigate the relationship between iron absorption and iron stores in patients with active rheumatoid arthritis.
  • To determine if defective iron absorption or intestinal malabsorption contributes to anemia in RA.

Main Methods:

  • Measured 59Fe absorption in patients with active rheumatoid arthritis.
  • Assessed bone marrow iron stores and serum ferritin concentrations simultaneously.
  • Utilized semiquantitative methods for assessing iron stores in the terminal duodenum in some cases.

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Main Results:

  • In 11 RA patients with increased bone marrow iron stores, iron absorption was decreased.
  • Five RA patients exhibited normal iron absorption.
  • Three RA patients with depleted bone marrow iron stores showed maximally increased iron absorption.

Conclusions:

  • Defective iron absorption is not the cause of anemia in rheumatoid arthritis.
  • Intestinal malabsorption can be excluded as a cause of anemia in this patient group.
  • Iron absorption is inversely related to iron stores in rheumatoid arthritis.