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Epidrugs: targeting epigenetic marks in cancer treatment

Cristiana Libardi Miranda Furtado1, Maria Claudia Dos Santos Luciano2, Renan Da Silva Santos2

  • 1Department of Surgery, Drug Research and Development Center, Federal University of Ceara , Fortaleza , Brazil.

Epigenetics
|July 9, 2019
PubMed

Insights

Aberrant epigenetic regulation drives cancer genesis. Reprogramming the cancer epigenome offers promising therapeutic strategies and reversibility for drug resistance, impacting personalized cancer treatment.

Area of Science:

  • Oncology
  • Epigenetics
  • Pharmacogenomics

Background:

  • Aberrant epigenetic regulation is linked to cancer development.
  • Epigenetic alterations influence individual drug responses in cancer patients.
  • The reversibility of epigenetic changes presents therapeutic opportunities.

Purpose of the Study:

  • To review the role of epigenetic reprogramming in tumorigenesis.
  • To highlight the targeting of epigenetic markers as cancer therapy (epidrugs).
  • To discuss the clinical implications of pharmaco(epi)genomics in cancer treatment.

Main Methods:

  • Literature review of epigenetic reprogramming in cancer.
  • Analysis of epidrugs targeting epigenetic markers.
  • Discussion of clinical applications and challenges.

Main Results:

  • Epigenetic reprogramming is a key factor in cancer development.
  • Epidrugs show potential for cancer treatment and overcoming drug resistance.
  • Pharmaco(epi)genomics offers personalized treatment strategies.

Conclusions:

  • Targeting epigenetic modifications is a promising avenue for cancer therapy.
  • Understanding epigenetic alterations can improve drug efficacy and reduce resistance.
  • Pharmaco(epi)genomics holds significant potential for precision oncology.
Keywords:
Epigeneticscancerepidrugspharmacologyreprogrammingtreatment

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