Related Experiment Video
Updated: Jan 22, 2026

Using Nanoplasmon-Enhanced Scattering and Low-Magnification Microscope Imaging to Quantify Tumor-Derived Exosomes
Published on: May 24, 2019
Mesenchymal derived exosomes enhance recovery of motor function in a monkey model of cortical injury
T L Moore1, B G E Bowley1, M A Pessina1
1Department of Anatomy & Neurobiology, Boston University School of Medicine, Boston, MA.
Background:
Exosomes from mesenchymal stromal cells (MSCs) are endosome-derived vesicles that have been shown to enhance functional recovery in rodent models of stroke.
Objective:
Building on these findings, we tested exosomes as a treatment in monkeys with cortical injury.
Methods:
After being trained on a task of fine motor function of the hand, monkeys received a cortical injury to the hand representation in primary motor cortex. Twenty-four hours later and again 14 days after injury, monkeys received exosomes or vehicle control. Recovery of motor function was followed for 12 weeks.
Results:
Compared to monkeys that received vehicle, exosome treated monkeys returned to pre-operative grasp patterns and latency to retrieve a food reward in the first three-five weeks of recovery.
Conclusions:
These results provide evidence that in monkeys exosomes delivered after cortical injury enhance recovery of motor function.
Related Concept Videos
Derivatives of the Trigonometric Functions
Derivatives of Logarithmic Functions
Derivatives of Simple Functions
Second Derivatives of Implicit Functions
Derivatives of Inverse Trigonometric Functions
Inverse Hyperbolic Functions and Their Derivatives

