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Related Experiment Video

Updated: Jan 22, 2026

Whole-Brain 3D Activation and Functional Connectivity Mapping in Mice using Transcranial Functional Ultrasound Imaging

Whole-Brain 3D Activation and Functional Connectivity Mapping in Mice using Transcranial Functional Ultrasound Imaging

Published on: February 24, 2021

Aberrant brain structural-functional connectivity coupling in euthymic bipolar disorder.

Ruibin Zhang^1,2,3, Robin Shao², Guiyun Xu^1,4,5

¹Department of Affective Disorders, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China.

Human Brain Mapping

|July 9, 2019

Summary

Structural and functional brain connectivity differences are key in bipolar disorder. Decreased structural-functional coupling strength in bipolar disorder patients may help identify individuals and inform prevention strategies.

Keywords:

bipolar disorder modularity predictive analysis rich club structural-functional coupling

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Area of Science:

Neuroimaging
Psychiatry
Systems Neuroscience

Background:

Aberrant structural and functional brain connectivity are hallmarks of bipolar disorder.
Limited research has investigated the agreement between structural and functional connectivity (SC-FC) in bipolar disorder.

Purpose of the Study:

To evaluate if the structural-functional connectivity coupling index offers clinical predictive value for bipolar disorder spectrum disorders.
To assess whether SC-FC coupling provides additional information beyond intramodality network measures.

Main Methods:

Utilized diffusion tensor imaging (DTI) for structural connectivity and resting-state functional magnetic resonance imaging (rs-fMRI) for functional connectivity.
Analyzed network properties and SC-FC coupling index in 57 euthymic bipolar disorder patients and 42 healthy controls (ages 13-28).

Main Results:

Bipolar disorder patients exhibited increased structural rich-club connectivity and decreased functional modularity compared to controls.
Significantly decreased structural-functional connectome coupling strength was observed in patients, serving as a key discriminating feature.

Conclusions:

Structural-functional coupling strength is a potential valuable trait-like biomarker for bipolar disorder, surpassing intramodality network measures.
This measure holds promise for early identification, prevention of onset, and relapse management in bipolar disorder.