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Cancer-Critical Genes I: Proto-oncogenes

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

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Related Experiment Video

Updated: Jan 22, 2026

Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line

Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line

Published on: April 11, 2025

How TP53 (almost) became an oncogene

Robert A Weinberg¹

¹Whitehead Institute for Biomedical Research, Ludwig/MIT Center for Molecular Oncology, MIT Department of Biology, Cambridge, MA 02142, USA.

Journal of Molecular Cell Biology

|July 9, 2019

Summary

No abstract available in PubMed .

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