Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Statistical Software for Data Analysis and Clinical Trials01:12

Statistical Software for Data Analysis and Clinical Trials

1.4K
Statistical software is pivotal in data analysis and clinical trials by providing tools to analyze data, draw conclusions, and make predictions. These software packages range from simple data management applications to complex analytical platforms, supporting various statistical tests, models, and simulation techniques. Their significance lies in their ability to handle vast amounts of data with precision and efficiency, enabling researchers to validate hypotheses, identify trends, and make...
1.4K
Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

Aneurysm II: Clinical Manifestations and Diagnostic Studies

315
Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
315
Comparative Excretory Systems02:24

Comparative Excretory Systems

26.5K
Animals have evolved different strategies for excretion, the removal of waste from the body. Most waste must be dissolved in water to be excreted, so an animal’s excretory strategy directly affects its water balance.
26.5K
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

475
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
475
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

314
The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
314
Integration of Synaptic Events01:28

Integration of Synaptic Events

3.5K
Synaptic integration mainly includes the summation of graded potentials. Graded potentials, regardless of their type, cause subtle alterations in membrane voltage, resulting in either depolarization or hyperpolarization. These incremental changes, when combined or summed, can propel the neuron toward its threshold. Consider, for example, a membrane experiencing a +15 mV shift, causing it to depolarize from -70 mV to -55 mV. In this scenario, graded potentials govern the membrane's ability to...
3.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sample Size Determination for Response-Adaptive Randomization With Recurrent Event Responses and Unequal Follow-Up Time.

Statistics in medicine·2026
Same author

Arthralgia and Ultrasound Characteristics of Subclinical Psoriatic Arthritis: A Cross-Sectional Study Based on the SPAWCH Cohort.

The Journal of dermatology·2026
Same author

Racial and ethnic disparities in access to acute stroke capabilities in California: Association with rurality and telestroke access.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association·2026
Same author

DDR2 ameliorates nonalcoholic hepatic steatosis by activating the AMPK/ACC pathway.

Scientific reports·2026
Same author

A Predictive Coding Model-based Sound Therapy for Patients With Subjective Tinnitus: A Pilot Study.

Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·2026
Same author

Anatomical observation of phrenic nerve branch variations at the cervicothoracic junction and upper mediastinum: two case reports.

Folia morphologica·2026

Related Experiment Video

Updated: Jan 22, 2026

Author Spotlight: Automated Deep Brain Stimulation for Parkinson's Disease - Exploring the Possibilities and Challenges of Home Monitoring
06:32

Author Spotlight: Automated Deep Brain Stimulation for Parkinson's Disease - Exploring the Possibilities and Challenges of Home Monitoring

Published on: July 14, 2023

1.8K

Adaptive treatment allocation for comparative clinical studies with recurrent events data.

Jingya Gao1, Pei-Fang Su2, Feifang Hu3

  • 1School of Statistics, Renmin University of China, Beijing, China.

Biometrics
|July 9, 2019
PubMed
Summary

This study introduces a novel sequential response-adaptive treatment allocation method for clinical trials. It aims to reduce patient allocation to inferior treatments while maintaining statistical power, improving treatment efficiency.

Keywords:
adaptive designallocation ruledoubly adaptive biased coin designnegative binomial model

More Related Videos

Tumor Treating Field Therapy in Combination with Bevacizumab for the Treatment of Recurrent Glioblastoma
06:15

Tumor Treating Field Therapy in Combination with Bevacizumab for the Treatment of Recurrent Glioblastoma

Published on: October 27, 2014

27.8K
A Method to Study Adaptation to Left-Right Reversed Audition
07:14

A Method to Study Adaptation to Left-Right Reversed Audition

Published on: October 29, 2018

6.8K

Related Experiment Videos

Last Updated: Jan 22, 2026

Author Spotlight: Automated Deep Brain Stimulation for Parkinson's Disease - Exploring the Possibilities and Challenges of Home Monitoring
06:32

Author Spotlight: Automated Deep Brain Stimulation for Parkinson's Disease - Exploring the Possibilities and Challenges of Home Monitoring

Published on: July 14, 2023

1.8K
Tumor Treating Field Therapy in Combination with Bevacizumab for the Treatment of Recurrent Glioblastoma
06:15

Tumor Treating Field Therapy in Combination with Bevacizumab for the Treatment of Recurrent Glioblastoma

Published on: October 27, 2014

27.8K
A Method to Study Adaptation to Left-Right Reversed Audition
07:14

A Method to Study Adaptation to Left-Right Reversed Audition

Published on: October 29, 2018

6.8K

Area of Science:

  • Clinical Trials
  • Biostatistics
  • Medical Research

Background:

  • Recurrent event data analysis is crucial for comparing treatment efficacies in long-term clinical studies.
  • The negative binomial model is commonly used for recurrent event data, accounting for patient heterogeneity.
  • Balanced treatment allocation (equal sample sizes) is standard but may be suboptimal if one treatment is superior.

Purpose of the Study:

  • To develop a sequential response-adaptive treatment allocation procedure for clinical trials.
  • To reduce the number of subjects assigned to less-effective treatments.
  • To maintain comparable statistical power to balanced designs.

Main Methods:

  • A sequential response-adaptive treatment allocation procedure was derived.
  • The procedure is based on the doubly adaptive biased coin design.
  • The method was illustrated by redesigning a clinical study.

Main Results:

  • The proposed allocation schemes effectively reduce the number of subjects receiving inferior treatments.
  • The statistical power of the proposed method is comparable to that of balanced designs.
  • The redesign demonstrated practical advantages of the new procedure.

Conclusions:

  • Sequential response-adaptive allocation offers an efficient alternative to balanced designs in clinical trials with recurrent events.
  • This approach optimizes resource allocation by minimizing exposure to less effective treatments.
  • The method provides a statistically sound way to improve clinical trial efficiency and patient outcomes.