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Effect of 5-hydroxytryptophan on H-reflex recovery curves in normal subjects and patients with affective disorders
J T Metz1, H H Holcomb, H Y Meltzer
1Department of Psychiatry, University of Chicago, IL.
Biological Psychiatry
|March 15, 1988
Abstract:
The effect of the serotonin precursor DL-5-hydroxytryptophan (5-HTP) on the Hoffmann reflex recovery curve (HRRC) was studied in normal subjects and patients with affective illness. 5-HTP significantly decreased the HRRC in normal controls and in depressed and manic patients receiving treatment with lithium or antidepressants. 5-HTP increased the HRRC in unmedicated depressed and manic patients. These results provide further evidence for a serotonergic abnormality in the affective disorders.