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In Vivo Imaging-Driven Approaches to Study Virus Dissemination and Pathogenesis
Pradeep D Uchil1, Kelsey A Haugh1, Ruoxi Pi1
1Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut 06510, USA; email: pradeep.uchil@yale.edu, kelsey.haugh@yale.edu, ruoxi.pi@yale.edu, walther.mothes@yale.edu.
Annual Review of Virology
|July 9, 2019
Summary
New imaging technologies enable in vivo studies of viral pathogenesis, transforming how we understand and combat infectious diseases. This approach guides detailed tissue and cell analysis for faster therapeutic development.
Area of Science:
- Virology
- Infectious Diseases
- Medical Imaging
Background:
- Viruses cause numerous diseases and infect all life forms.
- In vitro virus culture is crucial for mechanistic studies but lacks in vivo relevance.
- Traditional methods for testing in vitro findings in vivo are time-consuming.
Purpose of the Study:
- To propose a top-down imaging approach for studying viral pathogenesis in vivo.
- To leverage advanced imaging for understanding virus spread and disease mechanisms.
- To highlight the potential of imaging tools in transforming infectious disease diagnosis and treatment.
Main Methods:
- Utilizing noninvasive whole-body imaging as a primary investigative tool.
- Employing multiple spatial and temporal resolutions for in vivo analysis.
- Guiding in-depth characterization of tissues, cell types, and spread pathways.
Main Results:
- A vision for a novel research paradigm in viral pathogenesis is presented.
- The approach facilitates elucidation of virus spread and pathogenesis mechanisms.
- Imaging technologies are poised to revolutionize clinical diagnosis and therapy.
Conclusions:
- Noninvasive whole-body imaging offers a powerful strategy for in vivo viral pathogenesis research.
- This top-down approach accelerates the understanding of virus-host interactions.
- Advancements in imaging tools will significantly impact the management of infectious diseases.
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