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Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

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Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
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Mitral Stenosis III: Medical Management01:26

Mitral Stenosis III: Medical Management

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Mitral stenosis, a condition marked by the narrowing of the mitral valve, necessitates an integrated approach for effective management. This approach includes preventative measures, medical therapy, and surgical interventions to reduce symptoms and prevent complications.PreventionPrevention of mitral stenosis primarily focuses on reducing the incidence of bacterial infections, particularly streptococcal infections, which can lead to rheumatic fever and subsequent valvular damage. Timely...
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Mitral Stenosis IV: Nursing Management01:27

Mitral Stenosis IV: Nursing Management

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A comprehensive nursing assessment is essential for patients with valvular heart disease, which involves any dysfunction of the heart valves that could impact blood flow and overall heart function.Subjective Data Collection:Chief Complaint and Present Illness: Start with the patient's primary concerns, focusing on the onset, duration, and progression of cardiac symptoms such as dyspnea, fatigue, chest pain, and palpitations.Past Medical History: Collect detailed information on any previous...
253
Cis-regulatory Sequences02:02

Cis-regulatory Sequences

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Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...
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Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

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Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
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Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

228
Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
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Related Experiment Video

Updated: Jan 22, 2026

Murine Model of Central Venous Stenosis using Aortocaval Fistula with an Outflow Stenosis
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Murine Model of Central Venous Stenosis using Aortocaval Fistula with an Outflow Stenosis

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Cervical Stenosis in Non-Syndromic Pierre Robin Sequence.

Amjed Abu-Ghname1, Mohamad Masoumy, Laura A Monson

  • 1Division of Plastic Surgery at Texas Children's Hospital/ Michael E. DeBakey, Department of Surgery, Baylor College of Medicine, Houston, TX.

The Journal of Craniofacial Surgery
|July 9, 2019
PubMed
Summary

Pierre Robin sequence infants may have undetected cervical instability. Early spine evaluation is crucial before procedures like mandibular distraction osteogenesis to prevent serious complications.

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Area of Science:

  • Pediatric Surgery
  • Neonatal Care
  • Orthopedic Surgery

Background:

  • Pierre Robin sequence (PRS) is characterized by micrognathia, glossoptosis, and airway obstruction.
  • PRS is associated with various congenital anomalies, including craniocervical pathologies.
  • Neonates with PRS often undergo airway assessments and neck manipulations, increasing risks.

Observation:

  • A neonate with non-syndromic PRS presented for mandibular distraction osteogenesis.
  • The infant developed abnormal motor activity post-intubation.
  • Radiologic investigation revealed cervical spine stenosis and craniocervical instability.

Findings:

  • The case highlights a potential complication of PRS management.
  • Undetected cervical instability poses significant risks during airway interventions.
  • Prompt diagnosis of craniocervical instability is essential.

Implications:

  • Preoperative cervical spine evaluation is critical for PRS patients.
  • High vigilance during neck manipulations in these infants is paramount.
  • This underscores the need for comprehensive pre-procedural assessments in high-risk neonates.