Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

1.8K
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
1.8K
Imaging Studies I: CT and MRI01:14

Imaging Studies I: CT and MRI

835
Introduction: MRI and CT scans are crucial advancements in medical imaging techniques, playing a vital role in diagnosing conditions related to the gastrointestinal (GI) system. Each scan serves distinct purposes, targets specific areas, and requires unique nursing duties.
Description of the Procedures
Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...
835
Imaging Studies for Cardiovascular System V: CT01:28

Imaging Studies for Cardiovascular System V: CT

307
Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
307
COPD: Management Using Bronchodilators and Corticosteroids01:26

COPD: Management Using Bronchodilators and Corticosteroids

752
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
752
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

426
Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
426
Adrenergic Receptors: ɑ Subtype01:31

Adrenergic Receptors: ɑ Subtype

2.8K
Adrenoceptors are classified into α and ꞵ classes based on their potencies to catecholamine agonists. α-adrenoceptors show the following order of catecholamine potency:
Adrenaline ≥ Noradrenaline >> Isoprenaline
α-adrenoceptors are further divided into α1 and α2-adrenoceptors.
α1-Adrenoceptors: These receptors are located postsynaptically on the effector organs and cause constriction of smooth muscle mediated by activation of phospholipase...
2.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Publisher Correction: Whole genome sequence analysis of pulmonary function and COPD in 44,287 multi-ancestry participants.

Genome biology·2026
Same author

Correlates of 5-year decline in 6-min walk distance in the COPDGene cohort.

Thorax·2026
Same author

Body Mass Index-related genetic factors and COPD imaging phenotypes.

Annals of the American Thoracic Society·2026
Same author

Integrative multi-omic analyses identify major axes of heterogeneity in chronic obstructive pulmonary disease and uncover their molecular contributors.

medRxiv : the preprint server for health sciences·2026
Same author

Whole genome sequence analysis of pulmonary function and COPD in 44,287 multi-ancestry participants.

Genome biology·2026
Same author

Switch-like methylation of functional pathways distinguishes COPD and idiopathic pulmonary fibrosis.

medRxiv : the preprint server for health sciences·2025

Related Experiment Video

Updated: Jan 22, 2026

Label-Free Identification of Lymphocyte Subtypes Using Three-Dimensional Quantitative Phase Imaging and Machine Learning
08:58

Label-Free Identification of Lymphocyte Subtypes Using Three-Dimensional Quantitative Phase Imaging and Machine Learning

Published on: November 19, 2018

13.0K

Subtyping COPD by Using Visual and Quantitative CT Imaging Features.

Jinkyeong Park1, Brian D Hobbs2, James D Crapo3

  • 1Channing Division of Network Medicine, Boston, MA; Department of Internal Medicine, Dongguk University Ilsan Hospital, Goyang-Si, Gyeonggi-do, South Korea.

Chest
|July 9, 2019
PubMed
Summary
This summary is machine-generated.

This study classified Chronic Obstructive Pulmonary Disease (COPD) into 10 subtypes using CT imaging. Mortality was highest in severe centrilobular emphysema (CLE) groups, highlighting distinct COPD progression pathways.

Keywords:
COPDCT imagingepidemiologyheterogeneitysubtype

More Related Videos

Monitoring Tumor Metastases and Osteolytic Lesions with Bioluminescence and Micro CT Imaging
08:04

Monitoring Tumor Metastases and Osteolytic Lesions with Bioluminescence and Micro CT Imaging

Published on: April 14, 2011

25.2K
Author Spotlight: Streamlining Visual Dynamics to Simplify Molecular Dynamics Simulations Using Gromacs
05:00

Author Spotlight: Streamlining Visual Dynamics to Simplify Molecular Dynamics Simulations Using Gromacs

Published on: August 9, 2024

1.9K

Related Experiment Videos

Last Updated: Jan 22, 2026

Label-Free Identification of Lymphocyte Subtypes Using Three-Dimensional Quantitative Phase Imaging and Machine Learning
08:58

Label-Free Identification of Lymphocyte Subtypes Using Three-Dimensional Quantitative Phase Imaging and Machine Learning

Published on: November 19, 2018

13.0K
Monitoring Tumor Metastases and Osteolytic Lesions with Bioluminescence and Micro CT Imaging
08:04

Monitoring Tumor Metastases and Osteolytic Lesions with Bioluminescence and Micro CT Imaging

Published on: April 14, 2011

25.2K
Author Spotlight: Streamlining Visual Dynamics to Simplify Molecular Dynamics Simulations Using Gromacs
05:00

Author Spotlight: Streamlining Visual Dynamics to Simplify Molecular Dynamics Simulations Using Gromacs

Published on: August 9, 2024

1.9K

Area of Science:

  • Pulmonary Medicine
  • Radiology
  • Medical Imaging Analysis

Background:

  • Chronic Obstructive Pulmonary Disease (COPD) heterogeneity is recognized, with previous studies using visual or quantitative CT evaluation to identify subtypes.
  • A systematic assessment integrating both visual and quantitative CT imaging classification for COPD subtypes was lacking.

Purpose of the Study:

  • To integrate visual emphysema patterns with quantitative imaging features and spirometry data to create a refined classification of COPD subtypes.
  • To assess demographic, physiological, disease progression, and mortality differences across 10 distinct, nonoverlapping CT imaging-defined COPD subtypes.

Main Methods:

  • Evaluation of 9,080 current and former smokers from the COPDGene study with volumetric inspiratory and expiratory CT scans.
  • Definition of 10 discrete CT imaging subtypes based on emphysema patterns (e.g., paraseptal emphysema, centrilobular emphysema) and quantitative metrics.
  • Comparison of baseline and 5-year longitudinal characteristics and mortality across the defined CT imaging subtypes.

Main Results:

  • Overall mortality significantly differed across subtypes (P < .01), with the highest rates in moderate to severe centrilobular emphysema (CLE) groups.
  • Unique patient groups were identified with "quantitative without visual emphysema" and "visual without quantitative emphysema," exhibiting mild COPD but at risk for progression.
  • Significant emphysema progression over 5 years was observed in subjects with paraseptal emphysema (PSE) and/or moderate to severe CLE compared to controls (P < .01).

Conclusions:

  • The combined visual and quantitative CT imaging approach effectively captures diverse pathological processes within COPD.
  • This integrated classification system offers a valuable method for reclassifying COPD types, reflecting underlying disease mechanisms.
  • The identified subtypes provide a basis for understanding differential disease progression and risk stratification in COPD.