Related Experiment Video
Updated: Jan 22, 2026
03:13
Author Spotlight: A Single-Entry Point Endoscopic Intraventricular Approach for Third Ventriculostomy and Pineal Biopsy
Published on: June 28, 2024
1.3K
Pineal Region Gliomas: A Single-Center Experience with 25 Cases
Denghui Li1, Rong Wen1, Yuan Gao1
1Neurosurgery Department of West China Hospital Affiliated to Sichuan University, Wuhou District, Chengdu, Sichuan Province, People's Republic of China.
World Neurosurgery
|July 9, 2019
Summary
Open surgery is the primary treatment for pineal region gliomas, offering a tolerable survival rate. Prognosis depends on glioma grade, with low-grade tumors showing better outcomes and high-grade tumors benefiting from younger patient age.
Area of Science:
- Neurosurgery
- Neuro-oncology
- Radiology
Background:
- Pineal region gliomas are rare tumors with limited understanding of their behavior and optimal treatment.
- Their complex anatomical location and scarcity pose challenges for research and clinical management.
Purpose of the Study:
- To review treatment outcomes for pineal region gliomas at West China hospital over five years.
- To identify key prognostic factors by analyzing patient data and existing literature.
Main Methods:
- Retrospective analysis of 25 patients with pineal region gliomas.
- Collection of data on medical history, imaging, treatments, pathology, and follow-up.
- Literature search to supplement findings.
Main Results:
- Pilocytic astrocytomas and glioblastomas were the most frequent subtypes.
- Open surgery was the predominant treatment, with radiosurgery and chemotherapy used adjunctively.
- Low-grade gliomas had a better prognosis than high-grade gliomas.
- Karnofsky Performance Status (≤60) predicted prognosis in low-grade gliomas; younger age (≤30) predicted better prognosis in high-grade gliomas.
Conclusions:
- Open surgery is the recommended first-line treatment for pineal region gliomas, demonstrating acceptable safety.
- Radiosurgery and chemotherapy serve as valuable adjuvant or alternative options when surgical intervention is not feasible.
Related Concept Videos
01:02The Pineal Gland
4.9K
The pineal gland, a diminutive endocrine structure named for its pinecone-shaped appearance, is situated atop the third ventricle within the diencephalon region of the forebrain. This gland, composed of secretory cells known as pinealocytes arranged in compact cords and clusters around dense particles of calcium salts, plays a pivotal role in hormonal regulation.
The primary secretion of the pineal gland is the hormone melatonin, derived from serotonin. The concentration of melatonin in the...
The primary secretion of the pineal gland is the hormone melatonin, derived from serotonin. The concentration of melatonin in the...
4.9K
02:33Lattice Centering and Coordination Number
11.4K
The structure of a crystalline solid, whether a metal or not, is best described by considering its simplest repeating unit, which is referred to as its unit cell. The unit cell consists of lattice points that represent the locations of atoms or ions. The entire structure then consists of this unit cell repeating in three dimensions. The three different types of unit cells present in the cubic lattice are illustrated in Figure 1.
Types of Unit Cells
Imagine taking a large number of identical...
Types of Unit Cells
Imagine taking a large number of identical...
11.4K
00:58Center of Gravity
6.6K
The center of gravity (COG) of an object is the point where the object's total weight is considered to be concentrated. Knowing the location of the center of gravity is useful when predicting the behavior of a moving object or designing static structures. In a uniform gravitational field, the center of gravity is similar to the center of mass (COM); yet, these two points can be positioned differently. For example, the Moon's center of mass lies very close to its geometric center, but...
6.6K
01:15Center of Gravity
2.1K
The center of gravity is the point at which an object's weight appears to be concentrated and can be used to balance the object perfectly. This point is essential in mechanics as it provides information regarding a body's stability and moments of inertia. The center of gravity does not always have to fall within the shape or boundaries of the body; it may also lie outside the body in certain cases.
To determine its location, the principle of moments can be utilized by dividing the object into...
To determine its location, the principle of moments can be utilized by dividing the object into...
2.1K
00:59Center of Mass
2.0K
The center of mass is the point at which the total mass of an object can be said to be concentrated. It is a fundamental principle in mechanics and physics that applies to all objects regardless of their shape or size. The center of gravity is the point at which an object’s weight appears to be concentrated and can be used to balance the object perfectly.
The knowledge of the center of mass can also help us to describe and predict the motion of objects. For example, when a ball is thrown...
The knowledge of the center of mass can also help us to describe and predict the motion of objects. For example, when a ball is thrown...
2.0K
01:03IR Frequency Region: Fingerprint Region
1.9K
IR spectra are divided into two main regions: the diagnostic region and the fingerprint region. The diagnostic region of the spectrum lies above 1500 cm−1. The absorptions resulting from single-bond vibrations of the N–H, C–H, and O–H stretch at higher wavenumbers and appear on the left side of the spectrum. The stretching absorptions of the C≡C and C≡N occur between 2100–2300 cm−1. In contrast, those arising from stretching absorptions of the...
1.9K