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Related Experiment Video

Updated: Jan 22, 2026

Real-Time Proxy-Control of Re-Parameterized Peripheral Signals using a Close-Loop Interface
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Real-time contextual feedback for close-loop control of navigation.

Judith Lim1, Tansu Celikel1

  • 1Department of Neurophysiology, Donders Institute for Brain, Cognition, and Behaviour, Radboud University, Nijmegen, The Netherlands.

Journal of Neural Engineering
|July 9, 2019
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Summary
This summary is machine-generated.

This study introduces PolyTouch, open-source software for real-time animal behavior tracking and closed-loop feedback. It enables rapid stimulus delivery, facilitating neuroscience research into brain-behavior interactions.

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Area of Science:

  • Neuroscience
  • Behavioral Science
  • Computational Neuroscience

Background:

  • Real-time detection of behavioral events is crucial for closed-loop control in neuroscience research.
  • Traditional methods using embedded sensors have limitations in capturing complex behaviors.
  • High-speed cameras offer rich data but face processing bottlenecks for real-time feedback.

Purpose of the Study:

  • To develop an open-source software solution for high-speed animal behavior tracking.
  • To enable low-latency closed-loop feedback for neuroscience experiments.
  • To facilitate the study of brain-behavior relationships in real-time.

Main Methods:

  • Developed PolyTouch, a JAVA-based open-source software for animal behavior tracking in large arenas.
  • Achieved an average latency of ~5.7 ms for closed-loop feedback, including stimulus delivery (e.g., auditory tone, TTL pulse).
  • Integrated a MATLAB wrapper for enhanced experimental flexibility in data acquisition, analysis, and visualization.

Main Results:

  • Successfully deployed PolyTouch for place awareness training in mice.
  • Demonstrated that mice develop awareness to virtual spaces, altering their behavior in response to auditory feedback.
  • Showed that closed-loop aversive feedback can condition mice to avoid virtual targets within a single session.

Conclusions:

  • PolyTouch provides a powerful tool for real-time behavioral analysis and closed-loop experiments.
  • The software enables precise control over stimulus delivery based on animal behavior.
  • This technology advances the investigation of neural mechanisms underlying behavior and environmental context processing.