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Semi-quantitative Detection of RNA-dependent RNA Polymerase Activity of Human Telomerase Reverse Transcriptase Protein
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Telomerase Reverse Transcriptase (TERT) in Action: Cross-Talking with Epigenetics.

Xiaotian Yuan1,2, Dawei Xu3,4

  • 1School of Medicine, Shandong University, Jinan 250012, China. Xiaotian.Yan@ki.se.

International Journal of Molecular Sciences
|July 10, 2019
PubMed
Summary
This summary is machine-generated.

Telomerase reverse transcriptase (TERT) has non-canonical roles beyond telomere length extension. This review explores TERT

Keywords:
agingcancerepigeneticstelomerasetelomerase reverse transcriptase (TERT)telomere lengthening

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Area of Science:

  • Molecular Biology
  • Epigenetics
  • Oncology

Background:

  • Telomerase reverse transcriptase (TERT) is crucial for telomere maintenance.
  • TERT expression is tightly regulated in normal cells but activated in cancers.
  • TERT has functions beyond telomere elongation.

Purpose of the Study:

  • To review the non-canonical functions of TERT.
  • To emphasize TERT's cross-talk with epigenetics in physiological processes and cancer.
  • To discuss the clinical implications of TERT-related methylation.

Main Methods:

  • Literature review of TERT functions.
  • Analysis of TERT's interaction with epigenetic regulators.
  • Examination of TERT's role in cancer initiation and progression.

Main Results:

  • TERT interacts with chromatin remodelers and regulates DNA methylation.
  • TERT contributes to epigenetic alterations in normal and cancerous cells.
  • Aberrant epigenetics can facilitate TERT expression and function, promoting cancer.

Conclusions:

  • TERT possesses significant non-canonical functions involving epigenetic regulation.
  • TERT and epigenetics have a reciprocal relationship in cancer development.
  • TERT-mediated methylation has potential clinical implications.