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Programmed Death 1 Inhibitor-Induced Hypothyroidism on the Palliative Care Unit: Case Report
1Department of Medicine, University of British Columbia, Kelowna, British Columbia, Canada.
Abstract:
Novel immune-based cancer therapies such as programmed death 1 (PD-1) inhibitors continue to emerge for both curative and palliative intent. Post-market data of PD-1 inhibitors indicate that there are a wide range of side effects associated with these drugs, including ones that have relevance to symptom control and represent a diagnostic challenge at the end of life. We present a case of pembrolizumab-induced hypothyroidism causing extreme fatigue and persistent hypoglycemia.
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