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Updated: Jan 22, 2026

Humanized Mediator Release Assay as a Read-Out for Allergen Potency

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Published on: June 29, 2021

Allergen-like Molecules from Parasites.

Ju Yeong Kim^1,2, Myung-Hee Yi¹, Tai-Soon Yong¹

¹Department of Environmental Medical Biology, Institute of Tropical Medicine, and Arthropods of Medical Importance Resource Bank, Yonsei University College of Medicine, Seoul 03722, Korea.

Current Protein & Peptide Science

|July 10, 2019

Summary

This summary is machine-generated.

Parasite infections influence immune responses, potentially explaining fewer allergies. However, parasite proteins can trigger allergic reactions and cross-react with environmental allergens, complicating diagnosis and treatment.

Keywords:

Allergen Anisakis Echinococcus granulosus IgE-binding protein helminths parasite.

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Area of Science:

Immunology
Parasitology
Allergology

Background:

Declining parasitic infections correlate with rising allergic diseases in developed nations.
Parasites can exacerbate allergic responses by inducing specific immunoglobulin E (IgE) and type-2 immunity.
Parasite-derived molecules often mimic environmental allergens, leading to cross-reactivity.

Purpose of the Study:

To review the functions of IgE-binding proteins from helminthic parasites.
To explore the role of these proteins in modulating host immune responses.
To discuss their implications in allergy and potential vaccine development.

Main Methods:

Literature review of studies on parasite-host interactions.
Analysis of IgE-binding proteins from various helminthic parasites.
Examination of cross-reactivity with environmental allergens.

Main Results:

Parasite proteins, like those from Anisakis and Echinococcus granulosus, function as potent allergens.
IgE-binding proteins from helminths exhibit structural homology to common environmental allergens.
This cross-reactivity can lead to allergic symptoms and diagnostic challenges.

Conclusions:

Parasite IgE-binding proteins play a dual role, potentially contributing to allergies while offering insights for diagnostics and vaccines.
Understanding these proteins is crucial for managing allergic diseases and preventing parasitic infections.
Further research into parasite-host immune interactions is warranted.