Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Attribution Theory00:56

Attribution Theory

13.7K
Behavior is a product of both the situation (e.g., cultural influences, social roles, and the presence of bystanders) and of the person (e.g., personality characteristics). Subfields of psychology tend to focus on one influence or behavior over others. Situationism is the view that our behavior and actions are determined by our immediate environment and surroundings. In contrast, dispositionism holds that our behavior is determined by internal factors (Heider, 1958).
13.7K
Fundamental Attribution Error01:14

Fundamental Attribution Error

13.7K
According to some social psychologists, people tend to overemphasize internal factors as explanations—or attributions—for the behavior of other people. They tend to assume that the behavior of another person is a trait of that person, and to underestimate the power of the situation on the behavior of others. They tend to fail to recognize when the behavior of another is due to situational variables, and thus to the person’s state. This erroneous assumption is...
13.7K
Attribution01:26

Attribution

267
In social interactions, individuals frequently seek to understand the motivations and causes behind others' behaviors. This fundamental aspect of social perception, known as attribution, plays a crucial role in shaping interpersonal relationships and guiding future actions. Attribution refers to the cognitive process through which people infer the reasons behind others' behaviors, allowing them to assess character traits, intentions, and situational influences.Attribution Theory and Its...
267
Asthma-I: Introduction01:29

Asthma-I: Introduction

3.4K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
3.4K
Personal Choice and Fate Attributions01:19

Personal Choice and Fate Attributions

164
Some individuals interpret life events as a consequence of their personal choices and actions, while others believe that outcomes are dictated by fate or destiny. This divergence in perspective has been examined in psychological and cross-cultural studies, particularly in relation to religious faith and cultural beliefs about causality.Fate and Personal ResponsibilityPeople who emphasize personal responsibility view events as direct consequences of their decisions. For instance, breaking a leg...
164
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

4.2K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
4.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Suppressing Interfacial-Accelerated Degradation in Perovskite Solar Cells via Supramolecular Co-Assembly.

Angewandte Chemie (International ed. in English)·2026
Same author

Disease-specific differences in particulate matter handling drive pathogenic responses in human derived nasal epithelial cells.

bioRxiv : the preprint server for biology·2026
Same author

Sublimated Cyanoacetamide-Driven Surface Recrystallization for Spray-Coated Wide-Bandgap Perovskite Solar Cells.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

Crown Ether-Based Co-Self-Assembled Monolayer Enhances the Interaction with Perovskite for High-Performance Solar Cells.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

Viral and Host-Related Factors in the Nasal Inflammatory Response to Critical Bronchiolitis in Infants and Children.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·2026
Same author

Outcomes of children after initiation of home mechanical ventilation via tracheostomy: a single center retrospective study.

BMC pulmonary medicine·2026

Related Experiment Video

Updated: Jan 22, 2026

Acupuncture in a Rat Model of Asthma
07:14

Acupuncture in a Rat Model of Asthma

Published on: August 25, 2020

6.5K

Rhinovirus Attributes that Contribute to Asthma Development.

Mingyuan Han1, Charu Rajput1, Marc B Hershenson2

  • 1Department of Pediatrics and Communicable Diseases, University of Michigan Medical School, Medical Sciences Research Building II, 1150 West Medical Center Drive, Ann Arbor, MI, USA.

Immunology and Allergy Clinics of North America
|July 10, 2019
PubMed
Summary

Early-life infections with human rhinovirus (HRV) trigger asthma development in young mice by promoting a type 2 immune response. This response involves specific cytokines and immune cells, leading to asthma-like symptoms.

Keywords:
AsthmaInnate lymphoid cellsRhinovirus

More Related Videos

Asthma Detection Research Based on Voice Signal Processing and Machine Learning
04:04

Asthma Detection Research Based on Voice Signal Processing and Machine Learning

Published on: July 22, 2025

943
Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
14:39

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

32.4K

Related Experiment Videos

Last Updated: Jan 22, 2026

Acupuncture in a Rat Model of Asthma
07:14

Acupuncture in a Rat Model of Asthma

Published on: August 25, 2020

6.5K
Asthma Detection Research Based on Voice Signal Processing and Machine Learning
04:04

Asthma Detection Research Based on Voice Signal Processing and Machine Learning

Published on: July 22, 2025

943
Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
14:39

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

32.4K

Area of Science:

  • Immunology
  • Respiratory Medicine
  • Pediatrics

Background:

  • Early-life infections, particularly with human rhinovirus (HRV), are strongly linked to the development of childhood asthma.
  • Immature immune systems in infants and young children exhibit a bias towards type 2 cytokine responses.
  • Airway hyperresponsiveness, inflammation, and mucous metaplasia are key features of asthma phenotypes.

Purpose of the Study:

  • To investigate the mechanisms by which HRV infection in early life contributes to asthma development.
  • To identify the immune cells and molecular pathways involved in HRV-induced asthma phenotypes in immature hosts.
  • To explore the role of innate cytokines and type 2 innate lymphoid cells in HRV-associated asthma.

Main Methods:

  • Utilized a mouse model comparing HRV infection in 6-day-old (immature) and adult mice.
  • Assessed immune responses, including type 2 cytokine expression (e.g., IL-13) and eosinophilic inflammation.
  • Investigated the role of interleukin-25 (IL-25), interleukin-33 (IL-33), and thymic stromal lymphopoietin (TSLP) released by airway epithelium.
  • Examined the dependence of the asthma phenotype on interleukin-13 (IL-13)-producing type 2 innate lymphoid cells (ILC2s).

Main Results:

  • HRV infection in 6-day-old mice, but not adult mice, resulted in augmented type 2 cytokine expression.
  • Immature mice exhibited significant eosinophilic inflammation, mucous metaplasia, and airway hyperresponsiveness following HRV infection.
  • The observed asthma phenotype was dependent on IL-13-producing ILC2s.
  • Expansion of ILC2s was contingent upon the release of innate cytokines IL-25, IL-33, and TSLP from the airway epithelium.

Conclusions:

  • Early-life HRV infection induces an asthma phenotype in immature mice via a mechanism dependent on IL-13-producing ILC2s.
  • Airway epithelial cells release innate cytokines (IL-25, IL-33, TSLP) that drive ILC2 expansion and subsequent asthma development.
  • Genetic factors in humans may influence susceptibility to HRV-induced childhood asthma.