Jove
Visualize
Contact Us

Related Concept Videos

Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

1.3K
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
1.3K
Asthma-I: Introduction01:29

Asthma-I: Introduction

3.4K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
3.4K
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

4.2K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
4.2K
Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

3.3K
Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
3.3K
Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

3.1K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
3.1K
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

740
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
740

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical phenotyping of asthma patients with elevated sputum eosinophils and low blood eosinophils: a post-hoc analysis of the multicentre ATLANTIS cohort.

EBioMedicine·2026
Same author

Resolving Diagnostic Discordance in Group 2 Pulmonary Hypertension Through Staged Physiologic Testing: Insights From PVDOMICS.

medRxiv : the preprint server for health sciences·2026
Same author

Highlights from the 2025 Symposium of the Collegium Internationale Allergologicum.

The Journal of allergy and clinical immunology·2026
Same author

Mechanical compression reduces CC16 expression and disrupts metabolic homeostasis in airway epithelial cells.

American journal of respiratory cell and molecular biology·2026
Same author

Unique Features of Nasal Airway and Airflow Improvement Post-Dupilumab: A Computational Cohort Study.

The Laryngoscope·2026
Same author

Early and Sustained Efficacy of Depemokimab in Type 2 Asthma: A Pooled Analysis of the SWIFT-1/-2 Studies.

The journal of allergy and clinical immunology. In practice·2026
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jan 22, 2026

Acupuncture in a Rat Model of Asthma
07:14

Acupuncture in a Rat Model of Asthma

Published on: August 25, 2020

6.5K

Bacteria in Asthma Pathogenesis.

Michael Insel1, Monica Kraft2

  • 1Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Department of Medicine, University of Arizona Health Sciences, University of Arizona College of Medicine - Tucson, 1501 North Campbell Avenue, PO Box 245017, Tucson, AZ 85724, USA.

Immunology and Allergy Clinics of North America
|July 10, 2019
PubMed
Summary

Airway bacteria in newborns aid immune development and prevent asthma. Later infections or microbiome changes can worsen asthma, impacting its development and severity.

Keywords:
AsthmaBacteriaImmunologyMicrobiology

More Related Videos

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
14:39

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

32.4K
Asthma Detection Research Based on Voice Signal Processing and Machine Learning
04:04

Asthma Detection Research Based on Voice Signal Processing and Machine Learning

Published on: July 22, 2025

943

Related Experiment Videos

Last Updated: Jan 22, 2026

Acupuncture in a Rat Model of Asthma
07:14

Acupuncture in a Rat Model of Asthma

Published on: August 25, 2020

6.5K
Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
14:39

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

32.4K
Asthma Detection Research Based on Voice Signal Processing and Machine Learning
04:04

Asthma Detection Research Based on Voice Signal Processing and Machine Learning

Published on: July 22, 2025

943

Area of Science:

  • Microbiology
  • Immunology
  • Respiratory Medicine

Background:

  • The airways are constantly exposed to airborne bacteria and oral microorganisms.
  • Early-life gut and airway bacteria are crucial for immune system maturation.
  • Disruptions to the microbiome later in life are linked to asthma.

Purpose of the Study:

  • To investigate the role of early-life microbial exposure in immune development.
  • To understand how bacterial infections and microbiome alterations influence asthma.
  • To explore the impact of microbial factors on asthma pathogenesis, persistence, and severity.

Main Methods:

  • Review of existing literature on airway microbiome and asthma.
  • Analysis of studies on neonatal immune development and microbial colonization.
  • Examination of research linking later-life infections and microbiome changes to asthma outcomes.

Main Results:

  • Neonatal bacteria in the airways and gut promote immune maturation.
  • These early microbes offer protection against the development of asthma.
  • Subsequent bacterial infections and microbiome disturbances are associated with asthma development and increased severity.

Conclusions:

  • The early-life airway and gastrointestinal microbiome plays a critical role in establishing immune tolerance and preventing asthma.
  • Alterations in the microbiome later in life can trigger or exacerbate asthma.
  • Understanding these microbial dynamics is key to developing targeted asthma prevention and treatment strategies.