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Advanced Glycation End Products and Risks for Chronic Diseases: Intervening Through Lifestyle Modification
Chandan Prasad1,2, Kathleen E Davis1,2, Victorine Imrhan1,2
1Department of Nutrition and Food Sciences, Texas Woman's University, Denton, Texas (CP, VI, SJ, PV).
Abstract:
Advanced glycation end products (AGEs) are a family of compounds of diverse chemical nature that are the products of nonenzymatic reactions between reducing sugars and proteins, lipids, or nucleic acids. AGEs bind to one or more of their multiple receptors (RAGE) found on a variety of cell types and elicit an array of biologic responses. In this review, we have summarized the data on the nature of AGEs and issues associated with their measurements, their receptors, and changes in their expression under different physiologic and disease states. Last, we have used this information to prescribe lifestyle choices to modulate AGE-RAGE cycle for better health.
Insights
Advanced glycation end products (AGEs) form from sugar reactions and impact health by binding to receptors (RAGE). Modulating the AGE-RAGE cycle through lifestyle choices can improve well-being.
Area of Science:
- Biochemistry
- Cell Biology
- Metabolic Health
Background:
- Advanced glycation end products (AGEs) are formed nonenzymatically from sugars reacting with proteins, lipids, or nucleic acids.
- AGEs interact with receptors for advanced glycation end products (RAGE) on various cell types.
- This interaction triggers diverse biological responses with implications for health and disease.
Purpose of the Study:
- To review the nature and measurement challenges of AGEs.
- To examine the role and expression of RAGE in physiological and disease states.
- To provide lifestyle recommendations for modulating the AGE-RAGE pathway.
Main Methods:
- Literature review of AGEs and RAGE.
- Analysis of AGE-RAGE expression in different conditions.
- Synthesis of data to inform lifestyle interventions.
Main Results:
- Detailed characterization of AGEs and their measurement complexities.
- Overview of RAGE biology and its altered expression in disease.
- Established link between AGE-RAGE signaling and various pathologies.
Conclusions:
- Understanding AGEs and RAGE is crucial for metabolic health.
- Lifestyle modifications can effectively target the AGE-RAGE axis.
- Modulating the AGE-RAGE cycle offers a promising strategy for health improvement.
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